摘要
目的分析2011-2014年宁波市新生儿出生缺陷发生情况,探究影响缺陷发生的相关因素。方法利用宁波市妇女儿童保健系统收集2011年9月至2014年8月宁波市新生儿的出生缺陷数据,并用χ~2检验分析可能与出生缺陷相关的危险因素。结果 2011-2014年,宁波市新生儿出生缺陷发生率呈波动上升趋势,从2011年9月至2012年8月的190.4/万上升到2013年9月至2014年8月的271.5/万。在常见类型的出生缺陷中,发生率最高的前五位分别为先天性心脏病、血管瘤、多指(趾)、外耳其他畸形、唇裂/腭裂。按系统分,出生缺陷分布最多的前五位分别为先天性心脏病、四肢畸形、颜面部畸形、皮肤畸形和泌尿系统畸形。新生儿的出生缺陷发生率与性别无相关性,与新生儿出生体质量、胎龄和多胎情况、父母亲年龄、职业和文化程度、母亲妊娠期疾病和家族遗传病史均具有相关性。结论宁波市新生儿出生缺陷情况依然严峻,需加强生殖健康教育、避免导致出生缺陷的高危因素、提高产前诊断技术、做好出生缺陷监测,以降低新生儿出生缺陷率,提高人口素质。
Objective To analyze the birth defects of newborn babies in Ningbo in 2011--2014, and to explore the related risk factors of birth defects. Methods Data of neonatal birth defects in Ningbo between Septem- ber 2011 and August 2014 was collected from Ningbo Women and Children＇s Health Care System. Chi-square test was applied to analyze the risk factors associated with birth defects. Results The rate of birth defects in Ningbo increased from 190.4 per 100 000 in 2011 to 271.5 per100 000 in 2014. The 5 most common birth de- fects were congenital heart disease, hemangioma, polydactyly, other outer ear deformities and cleft lip/pal- ate. The top 5 systematical birth defects were congenital heart defects, limb deformities, facial deformities, skin abnormalities and urinary tract malformation. Neonatal birth defects were closely related to birth weight and gestational age of newborn, multifetation as well as parent＇s age, occupation, education and diseases dur- ing pregnancy and family history of genetic diseases. Conclusions The rate of birth defect is still high in Ningbo. In order to reduce the rate of birth defects and to improve the quality of the population, we need to strengthen education about reproductive health, avoid the risk factors of birth defects, improve prenatal diag- nosis technology and complete the birth defects monitoring.
作者
李洁
吴军华
邱海燕
LI Jie WU Jun-hua QIU Hai-yan(Ningbo Women and Childrenls Hospital, Ningbo, Zhejiang 315012 , China)
出处
《中国预防医学杂志》
CAS
CSCD
2017年第5期334-340,共7页
Chinese Preventive Medicine
基金
浙江省医药卫生一般项目(2014KYA273)
宁波市社发择优委托项目(2011C51004)
宁波市创新团队项目(2014B82003)
关键词
出生缺陷
新生儿
监测
Birth defect
Newborn
Monitoring
作者简介
作者简介：李洁，硕士研究生，实习研究员，主要从事生殖医学研究工作
通讯作者：邱海燕，E-mail：qhy86@sina．com
