摘要
目的探讨重复经颅磁刺激（rTMS）及无抽搐电休克治疗（MECT）在不同时间点对抑郁症疗效和血清脑源性神经营养因子（BDNF）的影响及其相关性研究。方法将抑郁症患者分成rTMS组、MECT组和药物组。治疗前及治疗2、4、12周后分别评定3组患者的汉密尔顿抑郁量表（HAMD）评分，测定血清BDNF水平并分析其相关性。结果治疗2周后，rTMS组和MECT组患者的HAMD评分低于药物组，差异均有统计学意义（P〈0．01），rTMS组与MECT组的差异无统计学意义（P〉0．05）。治疗2周和4周后rTMS组及MECT组患者的血清BDNF水平高于药物组，差异均有统计学意义（P〈0．05），而rTMS组与MECT组的差异无统计学意义（P〉0．05）。治疗4周后患者的血清BDNF水平与其HAMD评分呈正相关（r=0．407，P〈0．05）。结论单纯抗抑郁药物治疗2周后对抑郁症状的改善及血清BDNF水平升高的效果不及抗抑郁药物加rTMS、MECT治疗。
Objective To explore the effects of repetitive transcranial magnetic stimulation （rTMS） and modified e- lectroconvulsive therapy （MECT） on the therapeutic efficacy and serum brain derived neurotrophic factor （BDNF） in pa- tients with depression at different time points, and to explore their correlation. Methods Patients were divided into three groups according to their corresponding treatments： a rTMS group, a MECT group and a drug treatment group. Their scores of Hamilton depression rating scale （HAMD） were evaluated and the levels of serum BDNF were determined before treatment, and at the end of Weeks 2, 4 and 12 after treatment. Meanwhile, the correlation between HAMD scores and BDNF levels was analyzed. Results At the end of Week 2, the rTMS and MECT groups produced significantly different HAMD scores than the drug treatment group （P 〈 0.01 ）. There was no statistically significant difference between the rT- MS and MECT groups （ P 〉 0.05 ）. At the end of Weeks 2 and 4, the rTMS and MECT groups produced significantly dif- ferent BDNF levels than the drug treatment group （ P 〈 O. 05 ）. There was no statistically significant difference between the rTMS and MECT groups （P 〉 0.05 ）. At the end of Week 4, the level of serum BDNF was positively related with HAMD scores （r =0.407, P 〈 0.05）. Conclusions Antidepressant drugs, rTMS, and MECT therapy can effectively improve the symptoms of patients with depression and increase BDNF levels. At the end of Week 2, antidepressant drugs can not improve depressive symptoms and serum BDNF levels as good as rTMS and MECT.
出处
《徐州医科大学学报》
CAS
2017年第4期262-265,共4页
Journal of Xuzhou Medical University
关键词
重复经颅磁刺激
无抽搐电休克治疗
抑郁症
脑源性神经营养因子
repetitive transeranial magnetic stimulation
modified electroconvulsive therapy
depression
brain de-rived neurotrophic factor
