摘要
目的探讨三磷酸腺苷结合盒超家族G家族成员2(ABCG2)、乙醛脱氢酶1(ALDH1)在卵巢子宫内膜异位症恶变中的表达和意义。方法采用免疫组织化学法检测38例卵巢子宫内膜异位症恶变患者(EMs恶变组),35例卵巢子宫内膜异位囊肿患者(EMs组),30例正常子宫内膜患者(对照组)中ABCG2、ALDH1蛋白的表达。结果 ABCG2、ALDH1在EMs恶变组中的阳性表达率明显高于EMs组及对照组,比较差异有统计学意义(P<0.05)。EMs恶变组中ABCG2、ALDH1的表达与患者年龄、痛经史及病理学类型无明显相关性,与血清CA125水平、病理分化程度及分期呈明显相关性(P<0.05);ABCG2的表达与ALDH1的表达无明显相关性(P>0.05)。结论 ABCG2、ALDH1可能与卵巢子宫内膜异位症恶变的发生、发展有关。
Objective To investigate the expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis. Methods The protein expressions of ABCG2 and ALDH1 were detected with immunohistochemistry in 38 cases of malignant transformation of ovarian endometriosis（EMs malignant transformation group）, 35 cases of endometriosis（EMs group）and 30 cases of normal endometrium（eontrol group）. Results The positive rates of ABCG2 and ALDH1 expressions in EMs malignant transformation group were significantly higher than those in EMs group and control group（P〈0.05）. The expressions of ABCG2 and ALDH1 were significantly associated with the serum CA125 level,differentiation and clinical stage of malignant transformation of ovarian endometriosis （P〈0.05） ,but were not related to the patientrs age, dysmenorrhea history and pathology type （P〉0.05）. There was no correlation between the expression of ABCG2 and ALDH1 in malignant transformation of ovarian endo metriosis（P〉0.05）. Conclusion The expressions of ABCG2 and ALDH1 might be involved in malignant transformation of ovarian endometriosis.
作者
刘颂平
田鑫
温坚
殷新明
Liu Songping Tian Xin Wen J ian Yin Xinming(Department of Obstetrics and Gynecology ,the Fourth Affiliated Hospital of J iangsu University, Zhenjiang , Jiangsu 212000, China)
出处
《重庆医学》
CAS
北大核心
2017年第14期1912-1914,共3页
Chongqing medicine
基金
江苏省自然科学基金资助项目(BK20140502)
江苏省"六大人才高峰"资助项目(2015-WSW-088)
吴阶平医学基金资助项目(320.6755.15023)
作者简介
刘颂平（1979-），副主任医师，硕士，主要从事子宫内膜异位症方面研究。
