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抗抑郁药物与抑郁症HPA轴功能关系的研究进展 被引量:29

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摘要 下丘脑-垂体-肾上腺(HPA)轴功能亢进是抑郁症的发病机制之一,也是抑郁症患者常见的神经生物学异常表现之一。在抗抑郁药物的干预下,可增加糖皮质激素受体的敏感性,减弱糖皮质激素抵抗,抑制HPA轴功能,恢复糖皮质激素对HPA轴的负反馈调节,下调HPA轴的活性,从而改善抑郁症状。
出处 《医药导报》 CAS 2017年第6期659-664,共6页 Herald of Medicine
作者简介 高之涵(1989-),女,河北沧州人,医师,在读硕士,主要研究方向:临床精神病学、中西医结合精神医学,电话:0571-88723157,E-mail:574892686@qq.com. 通信作者金卫东,男,主任医师,硕士生导师,硕士,从事精神病临床诊治工作.电话:0571-88723157,E-mail:wdjin@163.com.
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