摘要
目的探讨朗格汉斯细胞组织细胞增生症(LCH)的疾病特点。方法回顾性分析北京协和医院收治的122例LCH患者皮损表现、系统受累表现、影像学表现、实验室检查、免疫表型及治疗和预后情况。结果 LCH皮损形态多样,最常受累的器官为肺,其他易受累的部位有骨、皮肤、淋巴结、肝脏、脾脏、口腔、甲状腺等。多系统LCH患者较单系统LCH患者多见。单系统LCH多采用手术治疗,多系统LCH以联合化疗为主。结论 LCH临床表现多样,肺是最常见的受损器官;治疗可采用手术或化疗。
Objective To investigate the features of Langerhans cell histiocytosis（ LCH）. Method Skin lesions, systemic involvement, imaging characteristics, laboratory tests, immunophenotying, treatment response,and survival of 122 LCH patients treated at our center from February 1983 to August 2013 were retrospectively analyzed. Results LCH was associated with diverse skin lesions. Lung was the most involved organ,followed by bone, skin, lymph nodes, liver, spleen, oral cavity, and thyroid. Multisystem LCH was more common than single-system LCH. Single-system LCH was mostly treated by surgery,whereas multisystem LCH by combined chemotherapy. Conclusions LCH has diverse clinical manifestations,with lungs being the most often involved organ. Surgery or chemotherapy is the mainstream treatment.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2017年第2期206-210,共5页
Acta Academiae Medicinae Sinicae
作者简介
通信作者：刘跃华,电话：010-69151502,电子邮件：yuehualiu@263.net
