摘要
Klotho蛋白是近期发现的和衰老密切相关的蛋白,主要表达于肾小管上皮细胞和脑脉络膜。Klotho蛋白的高表达可以增加机体对氧化应激的抵抗。许多研究证实,在糖尿病肾病中,肾脏klotho的表达降低,并且通过调节磷酸盐代谢、抗氧化应激、抗肾脏纤维化、抗肾小球肥大、抗凋亡、抗炎症等途径保护肾功能。本文就klotho蛋白与糖尿病肾病的关系进行综述,探寻其在糖尿病肾病中的分子生物学机制。
Klotho is a recently discovered anti-aging protein and is primarily expressed in kidneys distal convoluted tubules and choroid plexus in the brain. Overexpression of Klotho increases resistance to oxidative stress. A previous study suggested a decrease in klotho protein in kidneys of patients and animals with diabetic nephropathy. Through adjustment of phosphate metabolism, inhibition of oxidative stress, anti renal fibrosis, restrain to kidney hypertrophy, inhibit apoptosis and anti-inflammatory to protect renal function. The aim of this article is to discuss the progress of research on the relationship between klotho protein and diabetic nephropathy, exploring the pathogenesis that klotho protein play in diabetic nephropathy.
作者
武晓碧
汪晓霞
张希尧
王婵媛
WU Xiao-bi WANG Xiao-xia ZHANG Xi-yao WANG Chan-yuan(Department of Endocrinology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China)
出处
《现代生物医学进展》
CAS
2017年第11期2174-2177,共4页
Progress in Modern Biomedicine
基金
黑龙江省留学归国科学基金项目(LC2009C34)
作者简介
作者简介：武晓碧（1989-），女，硕士研究生，主要研究方向：内分泌与代谢病，电话：15504660612，E-mail：282487201@qq．com
通讯作者：汪晓霞，教授，硕士，E-mail：xiaoxiawang2005@hotmail．com
