摘要
粒细胞缺乏伴口腔溃疡临床常见,特别是接受放化疗或免疫抑制剂治疗的恶性肿瘤、血液系统疾病患者。口腔溃疡合并感染,除局部感染表现外,其引起同源性败血症的案例少见。我们报告粒细胞缺乏伴口腔溃疡继发同源性败血症患者2例如下。1病例资料例1,女,22岁,因＂牙龈出血1周＂入院,确诊为急性重型再生障碍性贫血。
To investigate clinical features,preventions,therapies in patients with septicemia resulting from agranulocytosis with oral ulcer,we analyzed the pathogenesis, clinical manifestations,laboratory tests and therapies of 2 cases with septicemia resulting from agranulocytosis and oral ulcer,and reviewed the relevant literature. Of 2 cases,one patient was confirmed acute severe aplastic anemia,the other one with acute lymphoid leukemia received haploid allogeneic peripheral blood stem cell transplantation. Both of 2 cases had onset of fever with severe oral ul- cer under the condition of agranulocytosis. Both of them found cultivated bacteria from oral and blood culture （bilateral double bottle） was done at the same time. The culture result in one case was stenotrophomonas maltophilia, and the other one was candida tropicalis. According to the drug sensitivity tests, the anti-infection therapeutic regi- men was adjusted. Both of 2 patients were discharged with improved conditions. There was potential possibility that severe oral ulcer with systemic infections could result in septicemia during agranulocytosis phase. Oral secretion and blood culture would be helpful in guiding our treatment. Once the pathogenesis was confirmed, adjusting anti-infection therapeutic regimen according to the drug sensitivity tests would improve the conditions of patients.
出处
《临床血液学杂志》
CAS
2017年第2期233-235,共3页
Journal of Clinical Hematology
基金
国家自然科学基金(No:81270652
81570175)
关键词
粒细胞缺乏
口腔溃疡
败血症
预防
治疗
agranulocytosis
oral ulcer
septicemia
prevention
therapy
作者简介
通信作者：仇红霞，E-mail：qhx9805@126．com
