摘要
1例40岁女性患者,因甲状腺功能亢进,口服甲巯咪唑10 mg,tid,一个月后致粒细胞严重缺乏,考虑为口服甲巯咪唑所致,给予停用甲巯咪唑,同时给予注射重组人粒细胞刺激因子注射液进行治疗,11 d后WBC 5.54×10~9·L^(-1),中性粒细胞计数2.4×10~9·L^(-1)。提示应加强对使用甲巯咪唑治疗甲亢患者的用药教育,及时发现药源性疾病的相关危险因素,一旦出现可能的临床表现,应及时停药并进行有效治疗。
A 40-year-old female patient with hyperthyroidism had taken methimazole （10 mg, tid） for 1 month and developed severe neutropenia. Methimazole was stopped and injection of recombinant human granulocyte stimulating factor was given to the patient. About 11 days later, white blood cells count was 5.54 ×10^9L^-1 and neutrophils count was 2.4 × 109·L^-1. It is necessary to strengthen medicine education of methimazole and be aware of related risk factors of drug induced diseases in time. Once the clinical manifestation was suspicious, suspected drug should be withdrawaled and effective therapy should be applied to the patient.
出处
《中国药物应用与监测》
CAS
2017年第3期194-196,共3页
Chinese Journal of Drug Application and Monitoring
作者简介
[作者简介]李文斐,男,医师,主要从事临床医学工作.E-mail：liwenfei199481@foxmail.com
[通信作者]贾立华,女,副主任药师,主要从事临床药学工作.E-mail：jialihuayx@163.com
