摘要
目的分析丁苯酞软胶囊治疗缺血性脑卒中的临床疗效及其对患者认知功能和执行功能的影响。方法选取2015年4月—2016年4月昆明医科大学第二附属医院收治的缺血性脑卒中患者90例,按照入院顺序分为对照组和试验组,每组45例。对照组患者给予常规治疗,试验组患者在此基础上加用丁苯酞软胶囊治疗;两组患者均连续治疗3周。比较两组患者临床疗效,治疗前及治疗后1、3周美国国立卫生研究院卒中量表(NIHSS)评分,治疗后认知功能及执行功能,治疗期间不良反应发生情况。结果试验组患者临床疗效优于对照组(P<0.05)。治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后1周、3周试验组患者NIHSS评分低于对照组(P<0.05)。治疗后试验组患者蒙特利尔认知功能评估量表(Mo CA)评分高于对照组,WCST错误应答数、连续错误数少于对照组,完成分类数多于对照组(P<0.05)。治疗期间两组患者均未发生严重不良反应。结论丁苯酞软胶囊治疗缺血性脑卒中的临床疗效确切,可有效改善患者神经功能、认知功能及执行功能。
Objective To analyze the clinical effect of butylphthalide soft capsules on ischemic stroke and the impact on cognitive function and executive function. Methods A total of 90 patients with ischemic stroke were selected in the Second Affiliated Hospital of Kunming Medical University from April 2015 to April 2016,and they were divided into control group and test group according to visiting sequence, each of 45 cases. Patients of control group received conventional treatment, while patients of test group received extra butylphthalide soft capsules based on conventional treatment; both group continuously treated for 3 weeks. Clinical effect, NIHSS score before treatment, after 1 week and 3 weeks of treatment, cognitive function and executive function after treatment, and incidence of adverse reactions during the treatment were compared between the two groups. Results Clinical effect of test group was statistically significantly better than that of control group（ P 〈 0. 05）. No statistically significant differences of NIHSS score was found between the two groups before treatment（ P 〉 0. 05）,while NIHSS score of test group was statistically significantly lower that that of control group after 1 week and 3 weeks of treatment,respectively（ P 〈 0. 05）. After treatment,Mo CA score of test group was statistically significantly higher than that of control group,number of false response and continuous errors of WCST of test group was statistically significantly less than that of control group,respectively,while number of completing classification of WCST of test group was statistically significantly more than that of control group（ P 〈 0. 05）. No one of the two groups occurred any serious adverse reactions during the treatment. Conclusion Butylphthalide soft capsules has certain clinical effect in treating ischemic stroke, can effectively improve the neurological function,cognitive function and executive function.
出处
《实用心脑肺血管病杂志》
2017年第1期114-116,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
卒中
丁苯酞软胶囊
治疗结果
认知功能
执行功能
Stroke
Butylphthalide soft capsules
Treatment outcome
Cognitive function
Executive function
