摘要
为研究莫能菌素包合物的制备工艺,以β-环糊精为包合材料,采用饱和水溶液法制备莫能菌素β-环糊精包合物。用红外光谱法(IR)对包合物进行物相鉴定。以包合率为指标,运用正交设计法,确定最佳处方和工艺条件。IR结果表明,药物与环糊精形成了包合物。当投料比为3∶1,包合温度为40℃,搅拌时间1.5h时,该制备工艺最佳,包合率为57.54%。该制备工艺可行,扩大了莫能菌素的应用,为莫能菌素的剂型改进奠定了基础。
To study the preparation technology of inclusion compound carrying monensin,monensin was encapsulated withβ-cyclodextrin using saturated water solution.The phase identification of inclusion compound was examed by infra-red spectrum（IR）.Based on a comprehensive evaluation of inclusion efficiency,the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows：The proportion of the quality ofβ-cyclodextrin and monensin was3∶1,the temperature of inclusion was 40 ℃,and the time of inclusion was 1.5h.The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin.The study laid a foundation for improvement about dosage form of monensin.
作者
杨小云
付丽娜
陈洪轩
李见梅
张翠利
信建豪
YANG Xiao-yun FU Li-na CHEN Hong-xuan LI Jian-mei ZHANG Cui-li XIN Jian-hong(Huanghe Science ＆ Technology College, Zhengzhou 475001, China)
出处
《中国畜牧兽医》
CAS
北大核心
2017年第1期289-295,共7页
China Animal Husbandry & Veterinary Medicine
基金
黄河科技学院校级项目(KYZR201312)
关键词
莫能菌素包合物
Β-环糊精
饱和水溶液法
红外光谱法
包合率
inclusion compound of monensin
β-cyclodextrin
saturated water solution method
IR
inclusion rate
作者简介
杨小云（1985-），女，河南登封人，硕士，讲师，研究方向：现代给药系统和制剂新技术，E—mail：yqf19800622@126．com
通信作者：信建豪（1981-），男，河南镇平人，硕士，副教授，研究方向：食品、药物分析，E-mail：nilk4@163．com
