摘要
[目的]探讨全脑放疗对脑转移癌患者认知功能及前瞻性记忆的影响。[方法]选取2010年4月至2015年5月本院收治的行全脑放疗脑转移癌患者100例，在全脑放疗前1周、放疗后1周、1～6个月行总体认知功能[简易精神状态量表（MMsE）、词汇流畅性试验（VFT）、数字广度试验（DS）]及前瞻性记忆[基于事件前瞻性记忆（EBPM）、基于事件前瞻性记忆（TBPM）]评估并比较。[结果]放疗后1周患者MMSE、DS、VFT、EBPM均明显低于放疗前，差异有统计学意义（t=3．033，11．294，5．055，3．966，P〈0．05），放疗后1周TBPM与放疗前比较无明显变化（P〉0．05）；放疗前无神经系统症状患者放疗后MMSE、EBPM明显低于基线水平（P〈0．05），放疗后4个月达谷值，之后逐渐回升，放疗前有神经系统症状患者（MMSE≤26）放疗后MMSE、EBPM明显高于基线水平（P〈0．05），放疗后4个月达峰值，之后逐渐降低。[结论]全脑放疗对脑转移癌患者总体认知功能及前瞻性记忆有一定影响，其中对基于事件前瞻性记忆损伤较重，放疗后4个月认知功能损伤较显著，放疗前脑转移癌患者有无神经系统症状在放疗后认知功能变化存在单分离现象。
[Objective] To explore the effect of whole brain radiotherapy on the cognitive function and prospective memory in patients with brain metastases.[Methods] A total of 100 patients underwent whole brain radiotherapy for brain metastases（WBRT） admitted in the hospital from April 2010 to May 2015 were selected. In 1 week before the whole brain radiotherapy, 1 week and 1-6 months after radiotherapy, the overall cognitive function included mini-mental state Examination （MMSE）, Vocabulary fluency test （VFT）, digit span test （DS） and the prospective memory including event-based prospective memory （EBPM） and event-based prospective memory （TBPM） were assessed and compared.[Results] One week after the radiotherapy, MMSE, DS, VFT and EBPM were all significantly lower than those before radiotherapy , and the difference was statistically significant （ t = 3.033,11.294, 5.055, 3.966, P 〈0.05） ; 1 week after radiotherapy, TBPM had no significant change after radiotherapy（ P 〉0.05） ; MMSE and EBPM were significantly lower than the baseline in patients without neurological symptoms before radiotherapy（ P 〈0.05）, 4 months after radiotherapy , their MMSE and EBPM went to valley, and then gradually picked up, Patients with neurological symptoms before radiotherapy （MMSE≤ 26）, MMSE and EBPM were significantly higher than the baseline level after radiotherapy （ P 〈0.05）, 4 months after radiotherapy, they went to the peak, then gradually decreased. [Conclusion]Whole brain radiotherapy has a certain effect on the overall cognitive function and prospective memory in patients with brain metastases, especially on those event-based prospective memory. The cognitive impairment was more significant in 4 months after radiotherapy. Patients of metastatic brain cancer with neurological system symptoms before radiotherapy may meet single separation phenomenon in the change of cognitive function after radiotherapy.
出处
《医学临床研究》
CAS
2016年第10期1888-1891,共4页
Journal of Clinical Research
基金
承德市科学技术研究与发展计划项目（编号：20142120）
作者简介
通讯作者，E—mail：chanchanhu@126．com
