摘要
幽门螺杆菌是一种广泛定植于人胃黏膜的革兰阴性菌,与慢性胃炎、消化性溃疡、胃癌的发生密切相关,其可通过多种毒力因子逃避宿主的免疫反应以造成慢性感染。自噬是真核生物进化过程中的高度保守过程,可清除细胞内的病原微生物,对维持机体内坏境起重要作用,并可通过溶酶体对受损、衰老的细胞器及生物大分子等进行吞噬降解,以维持细胞内环境稳定。幽门螺杆菌能够入侵胃上皮细胞和某些免疫细胞,诱导自噬的发生,并可在自噬体中复制后被清除。
Helicobacter pylori is one of the most common Gram-negative bacterial pathogens in gastric mucosa, and the infection causes a variety of gastric disorders,including simple gastritis, peptic ulcer or gas- tric malignancies. It can use several mechanisms to evade both the innate and adaptive arms of the immune response, as a result,it can lead to chronic infection. Autophagy is a highly conserved process in eukaryotic evolution process,which can remove the intracellular pathogens and maintain ceUular homeostasis through the degradation of cargo such as long-lived proteins and damaged organelles in the lysosomal. Helicobacter pylori can invade gastric epithelial ceils and some immune cells and then induce autophagy, and be eliminated after replication in autophagosomes.
出处
《医学综述》
2016年第20期3969-3973,共5页
Medical Recapitulate
基金
云南省高校联合专项基金(2012FB027)
关键词
幽门螺杆菌
自噬
空泡毒素
自噬相关基因
Helicobacter pylori
Autophagy
Vacuolating cytotoxin
Autophagy related genes
作者简介
在读研究生
通讯作者E-mail：malanqing@aliyun．com
