摘要
目的：检测帕金森病（PD）患者血清活化T细胞趋化因子（RANTES）水平及炎症因子白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α的变化,探讨其在PD免疫异常发病机制中的作用。方法：采用ELISA法检测60例PD患者（PD组）和35名健康体检者（对照组）血清RANTES、IL-1β、IL-6、TNF-α水平,采用Hoehn-Yahr、UPDRS量表分别对PD患者进行病情评估,同时对2组年龄、性别、吸烟、饮酒、血糖、血压、血脂差异一般状况进行检查。结果：PD组患者血清RANTES、IL-1β、IL-6和TNF-α水平均显著高于对照组（P〈0.01）;PD 1~5期患者血清RANTES水平差异均有统计学意义（P〈0.05~P〈0.01）,而1~5期患者血清IL-1β、IL-6和TNF-α水平差异均无统计学意义（P〉0.05）;PD患者UPDR评分组间血清RANTES水平轻、中和重度组差异均有统计学意义（P〈0.01）,而IL-1β、IL-6和TNF-α水平轻、中和重度各组间差异均无统计学意义（P〉0.05）,且PD组血清RANTES水平与UPDRS评分呈显著正相关关系（P〈0.01）。结论：PD患者血清RANTES、IL-1β、IL-6、TNF-α水平均较对照组有显著升高,提示炎症因子可能发动并维持了PD的发病进程,可为PD患者早期发现、防治提供优先依据。
Objective：To detect the levels of serum activated T cells chemokines （RANTES） and inflammatory cytokines [ including interleukin（IL）-1 β, IL-6 and tumor necrosis factor（TNF）-α ] in Parkinson＇s disease（PD） patients, and explore its roles in abnormal immune pathogenesis of PD. Methods ：The serum levels of RANTES, IL-1 β, IL-6 and TNF-α in 60 PD patients （PD group） and 35 healthy people（ control group） were examined using the ELISA method. The disease of PD patients was evaluated using the UPDRS and Hoehn-Yahr score. The age, sex, smoking, drinking alcohol, blood glucose, blood pressure and blood lipid in two groups were examined. Results：The serum levels of the RANTES, IL-1 β, IL-6 and TNF-α in PD group were significantly higher than those in control group （P 〈 0.01 ）. The differences of the serum RANTES levels in stage 1 to 5 PD patients were statistically significant （ P 〈 0.05 to P 〈 0.01 ）, but for the differences of the serum levels of IL-1 β, IL-6 and TNF-α were not statistically significant（ P 〉 0.05 ）. The differences of the serum RANTES levels between the mild, moderate and severe PD patients identified by the UPDRS were statistically significant （P 〈 0.01 ） ,but for the differences of the levels of IL-1 β,1L-6 and TNF-α were not statistically significant （P 〉 0.05 ）, and the level of RANTES was significantly positive correlation with the UPDRS score （P 〈 0.01 ）. Conclusions：Compared with control group, the levels of RANTES, IL-1 β, IL-6 and TNF-α in PD patients increase, which suggest that the inflammatory cytokines may initiate and sustain the process of pathogenesis of PD, and provide the reference in early finding and treating the PD.
作者
时鹏
屈洪党
李强
陈育华
李倩倩
谢静
SHI Peng QU Hong-dang LI Qiang CHEN Yu-hua LI Qian-qian XIE Jing(Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, Chin)
出处
《蚌埠医学院学报》
CAS
2016年第9期1132-1135,共4页
Journal of Bengbu Medical College
基金
安徽省教育厅自然科学一般项目(KJ2015B094by)
作者简介
时鹏（1981-），男，博士研究生．
[通信作者]屈洪党，硕士研究生导师，主任医师，副教授．E—mail：qhd820@sohu．com
