摘要
目的：探讨结直肠癌及癌旁组织中i ASPP的表达及其临床意义。方法：采用免疫组化法检测i ASPP在55例结直肠癌组织及47例癌旁组织中的表达情况,分析iASPP表达与肿瘤浸润深度、分化程度、淋巴结转移的相互关系。结果：①结直肠癌组织中iASPP的阳性表达率高于癌旁组织（P〈0.01）;②在高、中和低分化结直肠癌组织中iASPP阳性表达与肿瘤细胞的分化程度有关（P〈0.01）;③在T1～T4期结肠直癌中,iASPP阳性表达与肿瘤浸润深度有关（P〈0.01）;4结直肠癌组织中i ASPP的表达与淋巴结是否转移有关（P〈0.01）。结论：结直肠癌组织中i ASPP的阳性表达率高于癌旁结肠组织,且其表达与肿瘤的分化、肿瘤浸润深度及淋巴结是否转移有关,可能为结直肠恶性肿瘤的诊断提供帮助。
Objective：To explore the significance and expression of i ASPP in colorectal cancer and its adjacent tissues. Methods：We usd immunohistochemical method to detect the expression of i ASPP in 54 cases of colorectal cancer tissue and 47 cases of para colorectal cancer tissues,and analyzed the correlations between the expressions of i ASPP and the pathologic typing,infiltrative depth,clinical stage and lymph node metastasis of colorectal cancer. Results：The positive expression rate of i ASPP was significantly higher in colorectal cancer tissues than that in adjacent tissues（P〈0.01）. The expressions of i ASPP in colorectal cancer tissues were related to the degree of tumor cells,infiltrative depth of tumor and lymph node metastasis（all P〈0.01）. Conclusion：The expression levels of i ASPP in colorectal cancer tissues was higher than that in colorectal cancer adjacent tissues. It may be related with tumor differetiation,infiltrative depth and lymph node metastasis. This may be useful for the diagnosis of colorectal malignant tumor.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第8期983-986,共4页
Journal of Nanjing Medical University(Natural Sciences)
