摘要
目的观察和探讨中医辨证论治对咳嗽变异性哮喘转变及预后的影响。方法选取86例咳嗽变异性哮喘者且参考随机数字表法,按照1:1比例将其随机分为观察组和对照组(每组43例),对照组采用常规治疗方法,包括祛除或减少咳嗽变异性哮喘发作的诱发因素以及给予茶碱类药物、普米克雾化吸入、神经调节剂和白三烯拮抗剂等;观察组在常规治疗方法基础上,根据中医理论,采用辨证论治法,且对两组患者治疗效果、临床症状及体征改善或消失时间、治疗期间不良事件和治疗后生活质量评分进行比较。结果观察组患者咳嗽变异性哮喘临床控制率53.49%,高于对照组,转变为哮喘9.30%、复发率18.60%、低于对照组,差异有统计学意义(P<0.05);咳嗽、气喘、哮鸣音改善时间及平均治疗时间较对照组缩短,差异有统计学意义(P<0.05);恶心呕吐、心悸、声音嘶哑、颤动发生率低于对照组,差异有统计学意义(P<0.05);生活质量评分优于对照组,差异有统计学意义(P<0.05)。结论中医辨证论治能防止咳嗽变异性哮喘的转变、改善预后,不失为一种行之有效的治疗手段,值得深入研究与推广。
Objective To observe and explore the influence of TCM theory of syndrome differentiation to change and prognosis of cough variant asthma. Methods 86 cases of patients with cough variant asthma was selected,and at the same time,referred to random number table method,according to the proportion of 1 ： 1,they were randomly divided into observation group and control group with 43 cases in each.Patients in control group were given conventional treatment,including dispel or reduce cough variant asthma inducing factors and giving and theophylline drugs,Mick atomization inhalation,nervous regulator and leukotriene antagonists,etc.According to TCM theory,on the basis of routine treatment,patients in observation group were given the syndrome differentiation treatment.The curative effects of two groups,clinical symptoms and signs improved or disappear time,adverse events during treatment and the quality of life scores after treatment of the two groups were compared and analyzed. Results Cough variant asthma clinical control rates of observation group was 53.49%,which was higher than that of control group with 9.30%.The recurrence rate of observation group was 18.60%,which was lower than that of control group （P 〈 0.05）.Cough,asthma,wheezing sound improvement,the average time and treatment time of observation group were shortened （P 〈 0.05）.Nausea and vomiting,heart palpitations,voice hoarse,fibrillation incidence of observation group were lower than those of control group （P 〈 0.05）.The quality of life score of observation group was better than that of control group （P 〈 0.05）. Conclusion TCM theory of syndrome differentiation can prevent cough variant asthma and improve the prognosis. It can be regarded as a kind of effective treatment means. It is worthy of further research and extension.
出处
《中国医药科学》
2016年第15期55-58,共4页
China Medicine And Pharmacy
关键词
咳嗽变异性哮喘
中医
辨证论治
转变
预后
Cough variant asthma
Doctor of traditional Chinese medicine
Treatment based on syndrome differentiation
Change
Prognosis
