摘要
目的 分析三维放疗联合紫杉醇化疗对食管癌气管食管沟淋巴结转移患者的临床疗效。方法 选择食管癌气管食管沟淋巴结转移患者58例,随机分为三维放疗＋紫杉醇脂质体化疗（治疗组）及单纯三维放疗（对照组）各29例。两组均给予三维放疗,总剂量为60 Gy,常规分割治疗2.0 Gy/次,5次/周,连续治疗6周结束。治疗组在此基础上,每周放疗前静脉滴注紫杉醇脂质体30 mg,1次/周,连续6周。随访3年,比较两组近期疗效、远期疗效及不良反应发生率。结果 治疗组总有效率及1~3年生存率均显著高于对照组,差异有统计学意义（P〈0.05）。两组主要不良反应发生率比较,差异无统计学意义（P〉0.05）。结论 三维放疗联合紫杉醇化疗对食管癌气管食管沟淋巴结转移患者疗效确切。
Objective To analyze the therapeutic effect of 3-dimensional conformal radiotherapy （3D-CRT） combined with paclitaxel liposome in the treatment of esophageal cancer with tracheoesophageal groove lymph node metastasis. Methods We selected 58 esophageal cancer patients with tracheoesophageal groove lymph node metastasis and randomly divide them into control group or treatment group,29 in each group. The both groups received 3D-CRT with total 60 gy radiation dose ：2.0 Gy once a day and 5 times a week for 6 weeks. In the treatment group,patients also received paclitaxel liposome （i. v） 30 mg once a week for 6 weeks. All the pa- tients were followed up for 3 year. The short-term effective rate, long-term effective rate and the occurrence rate of major adverse reaction were compared between the two groups. Results The total effective rate and survival rate in the treatment group were significantly higher than those in the control group （P 〈 0. 05）. There was no obvious difference in the occurrence of major adverse reactions be- tween the two groups （P 〉 0. 05 ）. Conclusion The combination of 3D-CRT with paclitaxel liposome has a good therapeutic effect for esophageal cancer with tracheoesophageal groove lymph node metastasis.
出处
《实用医院临床杂志》
2016年第5期67-70,共4页
Practical Journal of Clinical Medicine
关键词
食管癌
气管食管沟淋巴结转移
三维放疗
化疗
紫杉醇脂质体
疗效
Esophageal cancer
Tracheoesophageal groove lymph node metastasis
3 D-CRT
Paclitaxel liposome
Combination treatment
Therapeutic effect evaluation
