摘要
目的:制备茜草总醌固体分散体并考察其体外溶出性能。方法:采用溶剂-熔融法和溶剂法制备茜草总醌固体分散体,考察不同型号辅料对该固体分散体制备工艺的影响,分别以体外溶出度和溶解度为指标,确定该固体分散体的最优处方。结果:最佳处方为聚乙烯吡咯烷酮S-630-茜草总醌提取物(5∶1),采用溶剂法制备茜草总醌固体分散体,所得产物在1%十二烷基硫酸钠中的溶解度285.39 mg·L-1,为原料的3.6倍;60 min体外累积溶出度66.37%,约为原料的2倍。结论:该工艺制备的固体分散体性状良好,较好地改善了茜草总醌的溶解度,为以茜草为原料的相关固体制剂的开发提供参考。
Objective： To prepare solid dispersions of total quinones from Rubiae Radix et Rhizoma and evaluate its in vitro dissolution ability. Method： This solid dispersions was prepared by solvent-melting method and solvent method. Effect of different matrix on preparation technology were investigated,with solubility and in vitro dissolution performance as indexes, optimal formulation was confirmed. Result： This solid dispersions was prepared by solvent method,its optimal formulation was ratio of polyvinyl pyrrolidone（ PVP） S-630 and total quinones extract of Rubiae Radix et Rhizoma of 5∶1. Solubility of this solid dispersions in 1% sodium dodecyl sulfate（ SDS） were increased to 285. 39 mg·L- 1, in vitro cumulative dissolution within 60 min was 66. 37%.Conclusion： The prepared product has good characteristics,which is confirmed to enhance the solubility of total quinones extract of Rubiae Radix et Rhizoma. It can provide a reference for the development of solid preparation originated from Rubiae Radix et Rhizoma.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第15期9-13,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海市教委预算内项目(2011JW17)
关键词
茜草
固体分散体
聚乙二醇
差示扫描量热法
溶出度
聚乙烯吡咯烷酮
总醌
Rubiae Radix et Rhizoma
solid dispersion
polyethylene glycol
differential scanning calorimetry
dissolution
polyvinyl pyrrolidone
total quinones
作者简介
浦益琼，博士，讲师，从事中药新药和新剂型研究，Tel：021-51323068，E-mail：puyiq@163．com
[通讯作者]王冰，博士，副教授，从事中药微粒给药系统研究，Tel：021-51323123，E-mail：annabel-cn@163．com；
张彤，博士，教授，从事中药制药及中药分析技术研究，Tel：021-51322318，E-mail：zhangtdmj@hotmail．com
