摘要
目的探讨降压联合调脂治疗高血压病患者的临床效果及药学分析。方法回顾性分析2014年11月-2015年11月在本院收治的98例高血压患者临床资料,按治疗所用不同方法分为两组,对照组44例行单纯降压治疗,观察组54例在其基础上加用调脂药物治疗,比较两组血压及血脂变化情况。结果治疗前两组SBP、DBP水平比较差异无统计学意义（P〉0.05）,观察组治疗后SBP、DBP均比对照组低,差异具统计学意义（P〈0.05）;治疗前,两组血脂各指标水平比较差异无统计学意义（P〉0.05）,观察组治疗后TC、TG及LDL-C水平均低于对照组,HDL-C水平高于对照组,差异具统计学意义（P〈0.05）。结论高血压患者在早期服用降压药的同时配合他汀类调脂药物治疗,不仅可调节血脂,改善动脉弹性,且可延缓粥样硬化病变,控制血压稳定,减少心、脑血管等病发风险。
Objective To explore the clinical effect and pharmaceutical analysis of treatment with antihypertensive therapy combined with lipid-lowering therapy in hypertensive patients. Methods 98 cases＇ clinical data in our hospital from November 2014 to November 2015 which with hypertension were adopted retrospectively.And the patients were divided into two groups according to the different treatment methods.44 patients in control group were given routine antihypertensive therapy alone,54 cases in the observation group plus the basis of its lipid-lowering drug therapy.The changes in blood pressure and blood lipids were compared. Results Before treatment the SBP,DBP,hsCRP,BNP and LDL-C levels had no significantly significant in the two groups（P〉0.05）.After treatment SBP,DBP in observation group were lower than the control group（P〈0.05）,after treatment TC,TG and LDL-C levels in observation group were lower than the control group,HDL-C level was higher（P〈0.05）. Conclusion Hypertensive patients taking antihypertensive drugs in the early conjunction with statin therapy,not only lipid cholesterol,improve arterial elasticity,and may delay the atherosclerotic lesions,control of blood pressure stable,reduce the heart and cerebrovascular disease risk.
出处
《中国医药科学》
2016年第10期179-181,共3页
China Medicine And Pharmacy
关键词
降压
调脂
高血压
药学分析
Antihypertensive therapy
Lipid-lowering therapy
Hypertension
Pharmaceutical analysis
