摘要
目的分析新生儿无乳链球菌败血症患儿的临床特征和抗菌治疗所使用的药品，为临床治疗提供参考。方法回顾性分析2014年4月～2016年4月期间来我院诊治的28例无乳链球菌败血症患儿的资料、治疗措施及预后，以及无乳链球菌菌株的敏感程度。结果28例无乳链球菌败血症患儿中，早发型22例，晚发型6例；合并肺炎者21例（早发感染19例），合并化脓性脑膜炎患儿6例（晚发感染2例）；通过细菌培养结果表明其对青霉素、头孢曲松及万古霉素较为敏感，但是此细菌对克林霉素、红霉素的耐药率分别为75．0％及67．9％；对左氧氟沙星的耐药率为42．8％：对利奈唑胺的耐药菌株为1株，耐药率为3．6％。结论新生儿无乳链球菌菌株对很多抗菌药品的耐药率偏高，临床中主要以头孢菌素、青霉素及万古霉素为首选；针对合并化脓性脑膜炎的患儿，要尽早使用能够透过血脑屏障的抗菌药物进行治疗。
Objective To analyze the clinical characteristic of neonatal streptococcus agalactiae and the medication of antibiotic therapy and provide evidence for clinical treatment. Methods Retrospective analysis was adopted and the medical record, treatment scheme, prognosis and sensitivity of streptococcus agalactiae strain of 28 children with strep- tococcus agalactiae sepsis who were treated in our hospital from April 2014 to April 2016 were studied. Results 22 cases were early-onset and 6 cases were late-onset; 21 cases were complicated with pneumonia （19 cases were early- onset infection）, 6 cases were suppurative meningitis （2 cases were late-onset infection）; the bacteria was sensitive to penicillin, ceftriaxone and vancomycin according to the bacterial culture, and the drug resistance rate of the bacteria to clindamyein and erythrocin was 75.0% and 67.9% respectively; the drug resistance rate of the bacteria to levofloxaein was 42.8% and 1 strain was resistance to the linezolid and the rate was 3.6%. Conclusion The drug resistance rate of neonatal streptococcus agalactiae to multiple antibacterial drugs were high and cephalosporin, penicillin and van- comycin was the clinical priority; for the children complicated with suppurative meningitis, antibacterial drug that can penetrate the blood-brain barrier should be applied as soon as possible.
出处
《中国现代医生》
2016年第18期56-58,共3页
China Modern Doctor
关键词
新生儿
无乳链球菌
临床特点
抗菌治疗
Neonatal
Streptococcus agalactiae
Clinical characteristic
Antibiotic treatment
