摘要
目的探讨冠心病患者血清尿酸（SUA）与平均血小板体积（MPV）的关系,并分析二者对患者远期发生心血管事件的预测价值。方法纳入经选择性冠状动脉造影确诊的冠心病患者共488例。检测并记录患者入院时SUA和MPV。随访5年,收集并记录患者首次心血管事件的发生情况。结果冠心病患者的SUA、MPV中位数分别为298.00μmol/L、11.05 f L。相关分析结果显示,SUA与MPV、空腹血糖、低密度脂蛋白胆固醇、白细胞计数呈显著正相关（r=0.528,P〈0.001;r=0.321,P=0.015;r=0.412,P=0.027;r=0.215,P〈0.001）。将冠心病患者MPV影响因素行多元逐步回归分析,结果显示SUA与MPV仍然独立相关（r=0.265,P=0.0137）。5年随访期间共发生心血管事件169例。COX多元回归分析显示SUA、MPV均为冠心病患者远期心血管事件的独立预测因子（SUA：HR 1.69,95%CI 1.12~2.25,P=0.033;MPV：HR 1.19,95%CI 1.15~1.23,P=0.013）。结论 SUA和MPV呈独立正相关;SUA和MPV均可准确预测冠心病患者未来心血管事件发生风险。
Aim To investigate the relationship between serum uric acid（ SUA） and mean platelet volume（ MPV） in patients with coronary heart disease（ CHD）,and to analyze their predictive value for long-term cardiovascular events. Methods A total of 488 patients with CHD diagnosed by selective coronary angiography were included. SUA and MPV were detected and recorded in patients when admitted to hospital. The occurrence of first cardiovascular event in patients was collected and recorded during 5 years of follow-up. Results The median SUA and MPV in patients with CHD were 298.00 μmol / L and 11.05 f L,respectively. Correlation analysis showed that SUA was significantly positively correlated with MPV,fasting blood glucose,low density lipoprotein cholesterol,white blood cell count（ r = 0. 528,P 0.001; r = 0.321,P = 0.015; r = 0.412,P = 0.027; r = 0.215,P 0.001）. Multiple stepwise regression analysis was performed to analyze the effect factors of MPV in patients with CHD,and the result showed that SUA and MPV remained independently associated（ r = 0.265,P = 0.0137）. Cardiovascular events occurred in 169 cases during 5 years of follow-up.COX multivariate regression analysis showed that SUA and MPV were independent predictors of long-term cardiovascular events in patients with CHD（ SUA： HR 1. 69,95% CI 1. 12-2. 25,P = 0. 033; MPV： HR 1. 19,95% CI 1. 15-1. 23,P =0.013）. Conclusion SUA and MPV are independently positively correlated; both SUA and MPV can accurately predict the future risk of cardiovascular events in patients with CHD.
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第8期821-824,共4页
Chinese Journal of Arteriosclerosis
关键词
尿酸
平均血小板体积
冠心病
心血管事件
Serum Uric Acid
Mean Platelet Volume
Coronary Heart Disease
Cardiovascular Event
作者简介
巩洁，硕士，副主任医师，研究方向为冠心病及先天性心脏病的介入诊断及治疗，E-mail为744693087@qq．com。
任晖，硕士，主任医师，主要从事冠心病介入治疗，E-mail为renhui4019@163．com。
通讯作者郭雄，教授，博士研究生导师，主要从事流行病学及地方病研究，E-mail为guoxiong@163．com。
