摘要
目的:分析脑卒中对执行控制网络(ECN)功能连接度影响,观察针刺脑卒中患者阳陵泉穴的即刻效应,探讨其中枢疗效机制。方法:20例脑卒中患者行静息态及针刺阳陵泉即刻的功能磁共振成像(fMRI),20名健康受试者行静息态fMRI,应用独立成分分析法提取ECN成分,比较ECN功能连接度差异。结果:脑卒中患者相较于健康受试在ECN左侧额下回、额上回、额内侧回、扣带回及岛叶功能连接度降低;患者针刺后较针刺前在ECN表现为右侧额上回及额中回功能连接度降低;患者针刺即刻效应下ECN功能连接度与健康受试静息态比较未显示差异。结论:运动通路损伤影响执行控制网络功能,该现象可能是病灶对侧运动相关脑区代偿性激活增强的原因。针刺即刻效应下ECN功能连接度趋于正常,针刺或可通过减弱ECN对运动相关脑区的抑制作用,以促进脑功能重塑,帮助运动功能康复。
Objective: To analyze the resting state and immediate effects of acupuncture on executive control network(ECN) in stroke patients and explore the central mechanism of acupuncture by using functional magnetic resonance imaging(fMRI). Methods: Twenty stroke patients were recruited to lay in an fMRI in resting state and acupuncturing at GB34 state, while 20 health subjects were recruited to undergo resting state fMRI scanning. The functional connectivity(FC) of the ECN between two groups were analyzed and compared by using the independent component analysis. Results: Stroke patients showed significantly decreased FC in left inferior frontal gyrus, superior frontal gyrus, medial frontal gyrus, cingulate gyrus and insula of ECN. FC in right superior frontal gyrus and middle frontal gyrus of stroke patients was decreased than resting state after treating with acupuncturing at left GB34. There was no significant difference between stroke patients at acupuncture state and healthy subjects at resting state. Conclusion: The impaired motor pathway can influence the function of ECN, which may explain the phenomenon of compensatory activation in contralateral motor-related brain regions. In the immediate effect of acupuncture, the FC of ECN tended to be normal. Acupuncture might improve the recovery of motor function by reducing the inhibitory effect on the motorrelated brain regions.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2017年第5期2128-2131,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(No.81473667)~~
关键词
执行控制网络
脑卒中
针刺
阳陵泉
功能磁共振
Executive control network
Stroke
Acupuncture
Yanglingquan(GB34)
fMRI
