摘要
目的:分析NIHSS评分为0分的脑卒中患者认知功能损害特点、危险因素及中医证候要素特点,为脑卒中后认知障碍防治提供依据。方法:选择NIHSS评分为0分的脑卒中患者816例,观察其认知水平,采集基本资料、中医症状、舌象、脉象等信息,6个月后进行随访,观察认知功能变化,分析认知功能损害特点。根据认知功能下降与否分为认知功能下降组和非认知功能下降组,比较两组人群认知功能损害危险因素及中医症状、舌象、脉象及证候要素。结果:NIHSS评分为0分的脑卒中患者认知功能下降涉及视空间与执行能力、记忆力、计算力、语言等多方面,表现为大脑高级智能的全面下降。两组冠状动脉粥样硬化性心脏病史、脑卒中类型差异显著(P<0.01),证候要素分布呈现显著差异(P<0.01)。结论:冠状动脉粥样硬化性心脏病史、腔隙性脑梗死与NIHSS评分为0分的脑卒中患者认知功能下降相关,患者证候要素复杂多样,特别是认知功能下降的患者多以复合证候要素为主,症状表现形式多样。
Objective： To investigate the characteristic of cognitive impairments, risk factors and TCM syndrome element of stroke patients with a National Institute of Health stroke scale score（NIHSS） of 0 point, and to provide a basis for prevention and treatment of cognitive impairment after stroke. Methods： Eight hundred and sixteen cases of stroke patients with NIHSS of 0 point were recruited to observe cognitive level, collect basic information, TCM symptom, tongue manifestation and pulse manifestation, and follow these patients up after 6 months to observe the change of cognitive level and analyze the characteristic of cognitive impairments. The patients were divided into 2 groups： the cognitive impairments group and the no-cognitive impairments group, risk factors of cognitive impairments, TCM symptoms, tongue manifestation, pulse manifestation and syndrome element were compared. Results： The cognitive decline of patients with NIHSS of 0 point inloved view space with various aspects such as executive capacity, memory, calculation and language. There was significant difference in Mo CA scores, MMSE scores, coronary heart disease history and cerebral stroke type（P〈0.05）. The two groups had a significant difference in the rate of TCM syndrome elements（P〈0.05）. Conclusion： There was a positive relationship between cognitive decline and coronary heart disease history and cerebral infarction. TCM syndrome elements of stroke patients with NIHSS of 0 point were complex and diverse, especially for cognitive decline patients with more complex TCM symptoms.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第5期1812-1815,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局2010年度中医药行业科研专项(No.201007002)
国家中医药管理局2014年度中医药行业科研专项(No.201407001)
2011年北京市科技计划项目(No.Z111107056811040)
2013年首都临床特色应用研究(No.Z131107002213151)~~
作者简介
通讯作者：张允岭，北京市丰台区芳星园1区6号北京中医药大学东方医院实验中心，邮编：100078，电话：010-6769634 E-mail：yunlingzhang2004@163．com
