摘要
目的：探讨儿童哮喘与幽门螺杆菌（Hp）感染的相关性。方法：选择我院2012年5月~2015年5月收治的80例儿童哮喘患者作为研究对象,选取同期健康体检儿童40例作为对照组,比较两组Hp感染情况,同时采用双抗体夹心酶联免疫吸附法（ELISA）对血清Hp-IgG、Hp-CagA IgG、白介素（IL）-4、γ干扰素（IFN-γ）及IL-1β等指标进行检测,分析Hp感染与儿童哮喘相关性。结果：哮喘组及发作期患儿Hp感染阳性率显著高于对照组及缓解期儿童（P〈0.05）,血清Hp-IgG及Hp-CagAIgG阳性率明显低于对照组及缓解期儿童（P〈0.05）。血清IFN-γ水平在哮喘组及发作期患儿中显著低于对照组及缓解期儿童,且前者IL-4及IL-1β水平显著高于后者,差异具有统计学意义（P〈0.05）。Hp感染阳性与IL-1β浓度表现为明显正相关性（R=0.75,P〈0.05）。结论：儿童Hp感染与哮喘发病具有显著正相关性,提示Hp感染对儿童哮喘发病具有一定保护作用,但哮喘患儿持续Hp感染可加重其免疫紊乱,成为哮喘难以治愈的主要原因。
Objective：To investigate the correlation between childhood asthma and Helicobacter pylori（Hp）infection.Methods：A total of 80 cases of children with asthma who were treated in our hospital from May 2012 to May 2015 were selected as the research subjects,and 40 cases of healthy children were selected as control group,the Hp infection of the two groups of patients were compared,the double antibody sandwich enzyme-linked immunosorbent assay（ELISA）was used to detect the serum HP-IgG,HP-CagAIgG,interleukin（IL）-4,Hp,interferon（IFN）-γand IL-1β,etc.,and the correlation between Hp infection and asthma was analyzed.Results：The positive rates of Hp infection in asthma group and children in attack stage were significantly higher than those in control group and children in remission stage（P〈0.05）.The positive rates of serum HP-IgG and HP-CagAIgG in asthma group and children in attack stage were significantly lower than those in control group and children in remission stage（P〈0.05）.The serum levels of IFN-γin asthma group and children in attack stage were significantly lower than those in control group and children in remission stage while IL-4and IL-1βlevels in the former were significantly higher than those in the latter（P〈0.05）.The Hp infection positive had significant positive correlation with IL-1βconcentration（R=0.75,P〈0.05）.Conclusions：Hp infection in children has significant positive correlation with the incidence of asthma,suggesting that Hp infection has a certain protective effect on childhood asthma,but persistent Hp infection in children with asthma can aggravate the immune disorder,which is the main reason for the difficulty of treatment of asthma.
出处
《海南医学院学报》
CAS
2016年第13期1429-1431,共3页
Journal of Hainan Medical University
基金
2011年深圳市盐田区科技计划项目(医疗卫生类,2011-3-1-13)~~
作者简介
吴莹（1976-），女，本科，主治医师，电话：13760439418，电子信箱：yingwwuu@yeah．net。
