摘要
目的:探讨毛细支气管炎患儿血清细胞免疫因子IL-18、IFN-γ水平及其与病情严重程度的相关性。方法:(1)采用ELISA方法,检测68例毛细支气管炎患儿治疗前、后和随访2个月时的血清IL-18、IFN-γ水平变化;(2)将68例毛细支气管炎患儿按呼吸困难评分,分成轻度、中度和重度,采用ELISA方法检测各组患儿血清IL-18、IFN-γ水平变化。结果:(1)观察组患儿治疗前血清IFN-γ、IL-18水平明显低于对照组(P均<0.01),治疗后其水平升高,显著高于观察组治疗前,但仍低于对照组(P均<0.01);随诊2个月后,IL-18、IFN-γ水平接近对照组。(2)轻度毛细支气管炎患儿血清IL-18、IFN-γ水平与中度组比较差异无统计学意义(P>0.05),而明显高于重度组(P<0.01)。(3)治疗前毛细支气管炎血清IFN-γ水平与IL-18水平成正相关(r=0.58,P<0.01)。结论:毛细支气管炎患儿血清IL-18、IFN-γ水平均下降,并与病情严重程度有关。
Objective： To investigate the changes of serum levels of IL-18 and IFN-γ,and their correlation with the severity of bronchiolitis in children.Methods： Sixty eight children with bronchiolitis were studied.Serum levels of IL-18 and IFN-γ were measured by enzyme-linked immunosorbent assay（ELISA） in all cases before and after treatment.All cases were divided into mild group,moderate group and severe group based on dyspnea criteria,and the level of IFN-γ and IL-18 were measured.Results：（1） The levels of IFN-y and 11718 in children with bronchiolitis before treatment were significantly lower than that of normal group（All P 〈0.01）. They were increased in post-treatment group and significantly higherthan that of pre-treatment group, but still lower than that of normal control group（All P^0.01）. After two month period of follow-up, the levels of IFN-7 and IL-18 were similar to the normal control group. （2） The levels of serum IL-18 and IFN-y in mild group showed no significant difference when compared with moderate group, but were significantly higher than that of severe group（All P%0.01, respectively）. （2） The level of IL-18 in mild group was positively correlated with the level of IFN-7（r=0.58, P〈0.01）. Oonclusions： Serum levels of IL-18 and IFN-7 in children with bronchiolitis are imbalanced, and are corre- lated with the degree of severity of the illness.
出处
《海南医学院学报》
CAS
2011年第2期208-210,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110038)~~
作者简介
赵小飞（1970-），男，陕西韩城，副主任医师，学士。电话：13553455661，电子信箱：zhaoxlaofei70@163．com.
