摘要
目的:探讨2型糖尿病和干眼症的关系并分析2型糖尿病发生干眼症的危险因素。方法:纳入2型糖尿病患者220例为观察组和健康人群50例为对照组,采集所有研究对象眼表失衡指数(OSDI)、泪膜破裂时间(TBUT)、泪液分泌试验(SIt),以及观察组性别、年龄、糖尿病病程、血糖、Hb A1c、HOMA-IR、血清CRP,对比分析两组患者干眼症发病率及干眼症症状,采用多因素Logistic回归分析影响2型糖尿病发生干眼症的危险因素。结果:对照组干眼症发病率(9/100,9.00%)明显低于观察组(108/440眼,24.52%)(P<0.05)。观察组OSDI评分明显高于对照组(P<0.05)。观察组TBUT、SIt明显小于对照组,两组间差异有统计学意义(P<0.05)。性别、年龄、糖尿病病程、OSDI、TBUT、SIt、Hb A1c和2型糖尿病患者发生干眼症具有一定的相关性(P<0.05)。年龄、糖尿病病程、TBUT、Hb A1c是2型糖尿病患者发生干眼症的危险因素(B>0,OR>1)。结论:2型糖尿病和干眼症具有一定的相关性,糖尿病患者年龄、糖尿病病程、血糖控制水平是2型糖尿病发生干眼症的独立危险因素。
Objective: To research the relationship between type 2 diabetes and dry eyes and to analyze the risk factors of type 2 diabetes occurring with dry eyes. Methods: A total of the 220 patients with type 2 diabetes were included as the observation group and 50 cases of healthy people were chosen as the control group. Ocular surface disorder index (OSDI), tear break up time (TBUT), Schirmer I test (Sit) were collected from all subjects. The gender, age, duration of diabetes, blood glucose, HbAlc, HOMA-IR and serum CRP were detected in observation group. Compare the symptoms and morbidity of dry eyes between two groups. Use the multiariable Logistic re- gression to analyze the factors influencing type 2 diabetes patients with dry eyes. Results: The incidence of dry eyes was 9.00% (9/100) in control group, significantly lower than in observation group (108/440, 24.52%) (P〈0.05). OSDI score in observation group was obviously higher than in control group (P〈0.05). TBUT and Sit in observation group were obviously lower than in control group, and the differ- ences between two groups has statistically significance (P〈0.05). The gender, age, duration of diabetes, OSDI, TBUT, Sit, HbA 1 c of type 2 diabetes patients has certain correlation with occurrence of dry eyes (P〈0.05) through single factor analysis. The blood glucose levels, HOMA-IR, serum CRP has no significant correlation with dry eyes (P〉0.05). The age, duration of diabetes, TBUT, HbAlc in type 2 dia- betes patients were independent factors for occurrence of dry eyes by logistic regression analysis (B〉0, OR〉1). Conclusion: Type 2 dia- betes has certain relevance with dry eyes. The age of diabetic patients, duration of diabetes, blood sugar control levels are independent risk factors for type 2 diabetes occurring dry eyes.
作者
邓显峰
朱峰
陈伟
李国保
许玲
DENG Xian-feng;ZHU Feng;CHEN Wei;LI Guo-bao;XU Ling(Department of Ophthalmology,Shiyan Hospital Affiliated to Hubei University of Chinese Medicine,Shiyan,Hubei,442000,China; Department of Ophthalmology of Dongfang Medical Center,Shiyan,Hubei,442001,China; Department of Ophthalmology of Shiyan Taihe Hospital,Shiyan,Hubei,442000,China)
出处
《现代生物医学进展》
CAS
2016年第13期2503-2506,共4页
Progress in Modern Biomedicine
基金
湖北省卫生厅科研基金项目(WJ2009108)
关键词
2型糖尿病
干眼症
危险因素
回归分析
Type 2 diabetes
Dry eyes
Risk factors
Regression analysis
作者简介
邓显峰(1973-),男,副主任医师,研究方向:弱视、斜视临床治疗与研究,E-mail:1465770291@qq.com,电话:13886806686
