摘要
目的了解支原体感染情况及对常见抗菌药物的耐药状况,为指导临床合理用药提供依据。方法使用支原体培养、鉴定及药敏试剂盒,对临床收集的2 639例疑似泌尿生殖道感染患者的标本进行支原体的检测、鉴定及药敏试验。结果在2 639份标本中,支原体阳性333份,阳性率为12.6%。其中解脲脲原体单一阳性279份,占83.8%;人型支原体单一阳性23例,占6.9%;解脲脲原体和人型支原体混合阳性31例,占9.3%。女性患者支原体检出率(15.0%)高于男性患者(4.3%)。其中,31～40岁女性患者支原体培养阳性率高于其他年龄段患者,阳性率为23.6%。解脲脲原体对抗菌药物的敏感率依次为交沙霉素(98.6%)、美满霉素(96.4%)、多西环素(96.1%)、四环素(97.4%)和克拉霉素(87.1%);耐药率较高的是环丙沙星(80.2%)、司巴沙星(31.5%)和红霉素(26.2%)。结论泌尿生殖道支原体感染主要由解脲脲原体引起,临床上需对疑似支原体感染患者进行支原体的培养和药敏试验,经验治疗时建议选择交沙霉素、多西环素或美满霉素。
Objective To investigate mycoplasma infection and its resistance to common antimicrobial agents and provide evidence for guiding clinical rational drug use. Methods A total of 2 639 samples from patients suspected of genitourinary tract infection were collected. Mycoplasma culture, identification, and drug sensitivity kit were used to perform mycoplasma detection, identification, and drug sensitivity tests. Results Three hundred and thirty-three of 2 639 samples were mycoplasma-positive and the positive rate was 12.6%. Two hundred and seventy-nine （ 83.8% ） of these 333 samples were only Ureaplasma urealyh＇cum （Uu） -positive, 23 （6.9%） were only Mycoplasma hominis （Mh）-positive, and 31 （9.3%） were Uu and Mh-positive. The detection rate in female patients （15.0%） was higher than that in male patients （4.3%）. Mycoplasma-positive rate in 31 -40-year-old female patients （23.6%） was higher than that in patients of other age groups. Antibiotic susceptibility rates of Uu to josamycin, minocycline, doxycycline, tetracycline, clarithromycin, ciprofloxacin, sparfloxacin, and erythromycin were 98.6%, 96.4%, 96.1%, 97.4%, 87.1%, 80.2%, 31.5%, and 26.2%, respectively. Conclusion Mycoplasma genitourinary tract infection is mainly caused by Uu. It is necessary to perform mycoplasma culture and drug sensitivity test for patients suspected of mycoplasma infection. Josamycin, doxycycline, and minocycline are recommended for empirical treatment.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2016年第4期546-549,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
支原体
泌尿生殖道
耐药性
mycoplasma
urogenital tract
antimicrobial resistance
作者简介
肖淑珍（1988-），女，硕士生；电子信箱：zndxxsz@163．com。
[通信作者]王文奎，电子信箱：wenkuiwang@hotmail．com。
