摘要
目的探讨宫颈小细胞癌(SCCC)与亮氨酸拉链蛋白(FEZ1)的关系及临床价值。方法回顾性分析2009年1月至2014年10月间接受治疗的25例SCCC患者的临床资料。另外选取同期首次确诊的29例宫颈慢性炎患者和29例宫颈上皮内瘤变(CINⅢ)者、29例宫颈其他类型恶性肿瘤患者分别作为对照1组、对照2组和对照3组。比较SCCC组与对照3组患者的一般临床资料、FEZ1蛋白的表达情况以及临床病理特征与FEZ1蛋白的关系。结果 SCCC组与对照3组患者的平均总生存期(OS)、平均无进展生存期(PFS)、淋巴结转移率以及化疗比率间差异有统计学意义(P<0.01),国际妇产联盟分期(FIGO分期)、肿瘤直径等差异无统计学意义(P>0.05)。对照1组患者的FEZ1阳性表达率最高,其次为对照2组和对照3组,而SCCC组患者的FEZ1阳性表达率最低。SCCC组与各对照组的FEZ1蛋白阳性表达率间差异有统计学意义(均P<0.05)。有淋巴结转移者与无淋巴结转移者以及低、中、高分化者间的FEZ1蛋白阳性表达率差异均有统计学意义(均P<0.05)。结论 FEZ1蛋白阳性表达的缺失与SCCC的发生以及淋巴结转移相关,是辅助诊断SCCC的一个重要的潜在免疫组化指标。
Objective To analyze the relationship between small cell carcinoma of cervix（ SCCC）,other types of cervical carcinoma and fasciculation and elongation protein zeta-1（ FEZ1） protein and the clinical value of FEZ1 protein. Methods From January 2009 to October 2014 in Obstetrics and Gynecology Hospital Affliated to Fudan University,clinical data of 25 patients with SCCC was retrospectivelyanalyzed. 29 patients with chronic cervicitis,29 patients with cervical intraepithelial neoplasia Ⅲ（ CIN Ⅲ）and 29 patients with other types of cervical carcinoma at the same time were chosen as the control group 1,2,3. The general information between SCCC group and the expressions of FEZ1 protein in every group and the relationship between FEZ1 protein and clinical pathological features were analyzed. Results The average progression-free survival（ PFS）,average overall survival（ OS）,lymph node metastasis rate and chemotherapy ratio between SCCC group and control group 3 showed significant difference（ P〈0. 01）. The others such as International Federation of Gynecology and Obstetrics（ FIGO） stages,tumor diameter and so on showed no significant difference（ P〉0. 05）. The positive expression of FEZ1 protein in control group 1 was the highest,then the control group 2 and 3. It was the lowest in SCCC group. The positive expression of FEZ1 protein showed significant differences in SCCC group and control group 1,2,3（ P〈0. 05）. The positive expression of FEZ1 protein in lymph node metastasis group and non-lymph node metastasis group,in poorly differentiated,moderately differentiated and well-differentiated all showed significance differences（ P〈0. 05）. Conclusion The detection of the positive expression of FEZ1 protein may have correlation with the occurrence of SCCC and lymph node metastasis. It＇s an important potential immunohistochemical index in diagnosis of SCCC.
出处
《中国肿瘤临床与康复》
2016年第5期531-534,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
宫颈小细胞癌
宫颈肿瘤
亮氨酸拉链蛋白
淋巴结转移
免疫组化
Small cell carcinoma of cervix
Uterine cervical neoplasms
Fasciculation and elongation protein zeta-1
Lymph node metastasis
Immunohistochemistry
作者简介
顾彧，女，副主任医师，主要从事妇科专业。通信作者：顾彧，Email：415373664@qq．com。
