摘要
目的观察体温控制对重型颅脑损伤患者血清神经元特异性烯醇化酶(neuron specific enolase,NSE)及Tau蛋白水平的影响及意义。方法 96例重型颅脑损伤患者,随机分为体温控制组35例,亚低温组15例,常规降温组46例。检测各组治疗前及治疗第3、5、7天血清NSE及Tau蛋白水平,并进行比较。结果 3组治疗前NSE、Tau蛋白水平比较差异无统计学意义(P>0.05);治疗第7天,体温控制组、亚低温组血清NSE[(31.82±11.24)、(30.24±9.79)μg/L]、Tau蛋白[(25.67±9.47)、(26.67±10.61)ng/L]均较治疗前[(72.15±15.84)、(72.38±18.91)μg/L,(79.84±18.59)、(77.50±19.69)ng/L]明显下降(P<0.01),但组间比较差异无统计学意义(P>0.05);常规降温组治疗第7天血清NSE[(62.76±13.02)μg/L]、Tau蛋白[(57.50±15.09)ng/L]与治疗前[(75.43±12.83)μg/L、(80.83±17.36)ng/L]比较差异无统计学意义(P>0.05)。结论体温控制可降低重型颅脑损伤患者血清NSE及Tau蛋白水平,起到与亚低温相同的治疗效果。
Objective To explore the influence of temperature control on the serum levels of neuron specific enolase（NSE）and Tau protein in patients with severe craniocerebral injury and its significance.Methods Ninety-six patients with severe craniocerebral injury were randomly divided into temperature control group（n=35）,mild hypothermia group（n=15）,and routine hypothermia group（n=46）.The levels of serum NSE and Tau protein were detected and compared among groups before and after 3-,5-and 7-day treatment.Results There were no significant differences in the levels of NSE and Tau protein among three groups before treatment（P〉0.05）.The serum levels of NSE（（31.82±11.24）,（30.24±9.79）μg/L）and Tau protein（（25.67±9.47）,（26.67±10.61）ng/L）after 7-day treatment were significantly lower than those before treatment（（72.15±15.84）,（72.38±18.91）μg/L;（79.84±18.59）,（77.50±19.69）ng/L）in temperature control group and mild hypothermia group（P〈0.01）,but there were no significant differences between two groups（P〉0.05）.There were no significant differences in NSE and Tau protein levels after 7-day treatment（（62.76±13.02）μg/L,（57.50±15.09）ng/L）in comparison with those before treatment（（75.43±12.83）μg/L,（80.83±17.36）ng/L）in routine hypothermia group（P〉0.05）.Conclusion Temperature control could significantly reduce the serum levels of NSE and Tau protein in patients with severe craniocerebral injury,and has the same therapeutic effect as mild hypothermia therapy.
出处
《中华实用诊断与治疗杂志》
2016年第4期389-390,共2页
Journal of Chinese Practical Diagnosis and Therapy
