摘要
目的探讨奥沙利铂联合卡培他滨的新辅助化疗治疗进展期胃癌的临床疗效及安全性。方法选取2013年2月至2014年2月间收治的80例进展期胃癌患者,按照随机数字表法分为观察组和对照组,每组40例,观察组患者接受奥沙利铂联合卡培他滨的新辅助化疗,对照组患者接受表柔比星+顺铂+氟尿嘧啶(ECF)化疗,观察和比较两组患者治疗的临床疗效、毒副反应及1年生存率。结果与对照组相比,观察组患者总有效率明显升高(P<0.05);观察组患者胃肠道反应、骨髓抑制等不良反应发生率显著降低(P<0.05),而肝肾功能损伤、脱发、色素沉着等发生率无明显变化(P>0.05);观察组患者1年生存率明显提高,差异有统计学意义(P<0.05)。结论奥沙利铂联合卡培他滨的新辅助化疗治疗进展期胃癌的疗效显著、不良反应少,可明显提高患者生存率,值得临床推广。
Objective To explore the clinical efficacy and safety of oxaliplatin combined with capecitabine neoadjuvant chemotherapy in the treatment for advanced gastric cancer. Methods From February 2013 to February 2014 in Wuhan University People＇s Hospital,80 advanced gastric cancer patients were enrolled in the study and randomized into the control group（ epirubicin ＋ cisplatin ＋ fluorouracil,ECF chemotherapy） and the observation group（ oxaliplatin combined with capecitabine in the neoadjuvant chemotherapy） according to the random number method,40 patients per group. The observation group accepted oxaliplatin combined with capecitabine neoadjuvant chemotherapy and the control group accepted ECF chemotherapy. The clinical efficacy,toxicity,and 1-yr survival rate in the two groups were compared. Results Compared with the control group,the total effective rate was significantly increased in the observation group（ P〈0. 05）; the toxicity incidence of gastrointestinal reactions and bone marrow suppression were obviously reduced in the observation group（ P〈0. 05）,however the incidence comparison of liver and kidney function damage,hair loss,pigment deposition rate between the two groups were not significant changes（ P〈0. 05）; the 1-yr survival rate was significantly increased in the observation group（ P〈0. 05）. Conclusions Oxaliplatin combined with capecitabine neoadjuvant chemotherapy in the treatment for advanced gastric cancer could achieve significant efficacy and less toxicity,and obviously increase the patients＇ survival rate.It is worthy of clinical promotion.
出处
《中国肿瘤临床与康复》
2016年第3期261-263,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤
奥沙利铂
卡培他滨
新辅助化疗
Stomach neoplasms
Oxaliplatin
Capecitabine
Neoadjuvant chemotherapy
作者简介
肖康，男，主治医师，主要从事肿瘤内科专业。
通信作者：戈伟，Email：gewei514@126．com
