摘要
目的观察乳腺癌根治术后大剂量分割放疗和常规分割放疗的急性不良反应。方法随机选取我院2014年6月至2015年6月收治的乳腺癌改良根治术后放疗的111例患者，根据放疗的不同剂量分割方案分为常规分割组（CRT）和大分割组（HOFRT）。常规分割组63例，总DT50Gy，每次剂量2Gv，每周5次；大剂量分割组48例，总DT40．05Gy，每次2．67Gy，每周5次。结果常规分割组和大分割组的II级或以上急性放射性皮肤反应、放射性肺炎的发生率分别为36．5％与12．5％（x2=8．14，P〈0.01）、34．9％与27．1％（x2=0．78，P〉0．05）。结论乳腺癌根治术后大分割放疗方案的急性不良反应优于常规分割方案。
Objective To observe acute adverse reactions of hypofractionated and conventional fractionated radiotherapy in patients after radical mastectomy. Methods 111 patients after radical mastectomy prepared for radiotherapy in our hospital from June 2014 to June 2015 were selected and divided into conventional fractionated radiotherapy （CRT） group and hypofractionated radiotherapy （HOFRT） group according to the dose fractionation schemes. 63 cases in CRT group received 50 Gy （2.0 Gy per fraction and 5 fractions per week）; while 48 cases in HOFRT group received 40.05 Gy （2.67 Gy per fraction and 5 fractions per week）. Results The rate of class II or above acute radiation skin reactions was 36.5% in CRT group and 12.5% in HOFRT group （x2=8.14, P〈0.01）. The rate of radiation pneumonitis was 34.9% in CRT group and 27.1% in HOFRT group （x2=0.78, P〉0.05）. Conclusion The rate of acute adverse reactions of hypofractionated radiotherapy in patients after radical mastectomy is better than that of conventional fractionated radiotherapy.
出处
《国际医药卫生导报》
2016年第5期625-628,共4页
International Medicine and Health Guidance News
关键词
乳腺癌
放射治疗
改良根治术
大分割放疗
不良反应
Breast cancer
Radiotherapy
Modified mastectomy
Hypofractionation
Adverse reactions
作者简介
通信作者：何汇朗，E-mail：hehl@sysucc．org．cn
