摘要
目的探讨腹腔镜结直肠癌根治术对结直肠癌患者预后及胃肠激素的影响。方法将泸州医学院附属医院收治的结直肠癌患者随机分为观察组与对照组,观察组患者采用腹腔镜结直肠癌根治术治疗,对照组患者采用开腹结直肠癌根治术治疗。比较两组患者手术一般情况,术后并发症发生率,手术前后胃动素、胃泌素水平及免疫指标变化情况。结果观察组患者术中出血量、切口总长度、肛门排气时间、人均止痛次数、下床活动时间及住院时间均少于对照组(P<0.05),手术时间长于对照组(P<0.05)。两组患者淋巴结清扫数量比较差异无显著性(P>0.05)。观察组患者术后并发症发生率明显低于对照组(P<0.05)。对照组患者术后胃动素和胃泌素水平明显低于观察组(P<0.05)。两组患者术前、术后各免疫指标组间比较差异均无显著性(P>0.05)。观察组患者术后免疫球蛋白(Ig)A、Ig M水平较术前明显降低,C反应蛋白(CRP)水平较术前明显升高(P<0.05);对照组患者术后Ig A水平较术前明显降低,白细胞介素(IL)-6与CRP较术前明显升高(P<0.05)。结论腹腔镜结直肠癌根治术可有效改善结直肠癌患者治疗效果,减轻患者胃肠道不良反应,提高预后。
Objective To study the effect of laparoscopic colorectal cancer radical resection on the prognosis and gastrointestinal hormones in patients with rectal cancer. Method The patients with colorectal cancer were randomly divided into observation group and control group, observation group patients were treated by laparoscopic colorectal cancer radical treatment, control group patients were treated by open colorectal cancer radical treatment. Compared two groups of patients with surgery and general situation, the incidence of postoperative complications, postoperative gastric dynamic element, stomach secrete hormone levels before and after operation and immune index changes. Result Observation group of patients with intraoperative blood loss, total length of the incision, anal exhaust time, per capita number of pain relief, bed activity time and hospital stay were less than control group （P 〈 0.05）, the operation time was longer than control group （P 〈 0.05）, two groups of patients with cleaning the lymph node number had no significant difference （P 〉 0.05）. incidence of postoperative complications in patients with observation group was obviously lower than control group （P 〈 0.05）. The motilin and gastrin levels in control group were significantly lower than observation group （P 〈 0.05）. There were no significant differencesof preoperative and postoperative immune indexes between the two groups （P 〉 0.05）. The IgA and IgM levels in observation group were significantly lower than before operation, the CRP level was significantly higher than before operation （P 〈 0.05）. The IgA level in observation group was significantly lower than before operation, the IL-6 and CRP levels were significantly higher than before operation （P 〈 0.05）. Conclusion Laparoscopic radical resection of colorectal cancer can effectively improve the therapeutic effect of rectal cancer patients, reduce the adverse reactions of patients with gastrointestinal tract, improve the prognosis.
出处
《中国医学前沿杂志（电子版）》
2015年第12期54-57,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
腹腔镜
结直肠癌
根治术
胃肠道功能
Laparoscopy
Colorectal cancer
Resection
Gastrointestinal function
作者简介
通讯作者：赵和照E—mail：zhaohezha02015@sina．com
