摘要
目的:观察IgG1在不同严重程度支气管哮喘患者外周血清中的表达水平,并探讨其与B细胞分化水平及肺功能之间的相关性。方法:观察健康志愿者、哮喘患者及其治疗后外周血清中IgG1水平变化;比较不同严重程度哮喘患者血清中IgG1水平;统计学分析IgG1与B细胞分化及肺功能指标(FEV1/FVC、FEV1/Pre)之间的相关性。结果:哮喘患血清中IgG1水平显著高于正常对照组(P<0.01),治疗后哮喘患者IgG1水平显著下降(P<0.05);轻度、中度及重度哮喘患者IgG1水平有显著差异;IgG1水平与外周血淋巴细胞中B细胞分化水平存在正相关,与肺功能指标FEV1/FVC、FEV1/Pre均存在负相关。结论:IgG1在哮喘中分泌增加,治疗后下降,可能参与了哮喘B细胞的细胞免疫功能,并可能反映患者气流受限程度及疾病严重程度。
Objective：To observe the level of IgG1 in the plasma of asthma patients,and explore the correlation between IgG1 and the differentiation of B cells and the lung function of the patients.Methods：The level of IgG1 in the plasma of healthy controls,acute exacerbation and release period of asthma were detected.The correlations between IgG1 and the differentiation of B cells and the lung function（FEV1/FVC,FEV1/Pre）of the patients were also analyzed.Results：The level of IgG1 of asthma patients increased in acute exacerbation asthma patients compared with healthy controls（P〈0.01）.After treatment,the level of IgG1decreased（P〈0.05）in asthma patients.There was positive correlation between IgG1 and B cells differentiation,and negative correlation between IgG1 and lung function in asthma patients.Conclusion：The level of IgG1 in plasma increases in acute exacerbation asthma patients;IgG1may participate in the function of B cells in asthma,and may reflex the extent of airway limitation of asthma patients.
出处
《武汉大学学报（医学版）》
CAS
2016年第1期109-112,共4页
Medical Journal of Wuhan University
作者简介
王亮朝，男，1981-，医学硕士，主要从事慢性气道阻塞性疾病研究
通讯作者：赵苏，男，1955-，主任医师，主要从事慢性气道炎症及介入治疗
