摘要
目的探讨血清Cystatin C浓度在临床上判断肾功能早期损害的价值。方法对80例肾脏损伤的患者进行99m锝-二乙三胺五醋酸(99mTc-DTPA)清除率和血清Cystatin C浓度的测定,同时测定血清肌酐(Scr)、24小时肌酐清除率(24h Ccr)和采用Cockcroft-Gault公式计算肌酐清除率(Ccockcroft),以99m锝-二乙三胺五醋酸(99mTc-DTPA)清除率为标准方法,对结果进行相关分析。结果以上指标与血清Cystatin C均有相关关系,血清Cystatin C与99mTc-DTPA清除率有高度相关性,并且血清Cystatin C在Scr正常时已经升高。结论 Cystatin C浓度检测能够快速、准确和简捷的测定肾小球滤过率,能发现早期肾脏损害和肾功能改变。
Objective To discuss the clinical significance of serum Cystatin C concentration for glomerular filtration rate（GFR）. Method The concentration of Cystatin C, clearance of 99mTc-DTPA,serum creatinine（Scr） and 24h creatinine clearance（24hCcr） were evaluated in 80 patients with nephropathy. Creatinine clearance was also estimated by Cockcroft-Gault formula （Ccokcroft）. The clearance of 99mTc-DTPA was standard. The correlation analysis was performed. Results Tc-GFR, Scr,24hCcr and Ccokcroft were all correlated with Cystatin C concentration significantly. The level of Cystatin C was higher than normal while Scr was normal. Conclusion Serum Cystatin C concentration determination is a rapid,accurate and simple measurement of GFR and shows early damage clinically.
出处
《河南医学高等专科学校学报》
2015年第6期751-753,共3页
Journal of Henan Medical College
作者简介
邱冬（1977-），女。河南省周口市人，硕士，讲师，从事临床检验教学工作。
通讯作者：李敏霞，E—mail：minxial@126．com。
