摘要
目的研究血清胱抑素C(Cystatin C)和尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在儿童脓毒症早期肾损害中的诊断价值。方法选择在本院就诊的100例脓毒症患儿作为研究对象,根据肌酐清除率水平分为Ccr≥80mL/min的对照组、Ccr60～80mL/min的肾功能Ⅰ级组、Ccr40～59mL/min的肾功能Ⅱ级组,检测血清总Ccr、Scr、Urea、Cys C及尿液中NGAL含量。结果肾功能Ⅰ、Ⅱ级组患儿的Cys C、NGAL水平均明显高于对照组,且肾功能Ⅱ级组高于Ⅰ级组,Scr、Urea水平与对照组差异无统计学意义。结论血清Cystatin C和尿NGAL能够早期发现肾功能损害,且肾功能损害越严重,血清Cystatin C和尿NGAL水平越高。
Objective To study the diagnostic value of serum cystatin C and urinary neutrophil gelatinase-associated lipocalin （NGAL） in the early renal damage for children with sepsis. Methods 100 children with sepsis were selected as research subjects in our hospital,and divided into control group for creatinine clearance （Ccr） ≥80 mL/min,renal function Phase Ⅰfor Ccr at 60-80 mL/min,and renal function Phase Ⅱ for Ccr at 40-59 mL/min.Serum total Ccr, Scr, Urea, Cys C and urine NGAL were detected. Results Cys C and urinary NGAL in the renal function Phase ⅠandⅡ group were significantly higher than those in control group,and the levels in the renal function Phase Ⅱ group were higher than renal function Phase Ⅰ group, Scr, Urea levels were not different from control group. Conclusion Serum cystatin C and urinary NGAL can detect renal damage early.Renal damage is more severe,if the level of serum Cystatin C and urinary NGAL is higher.
出处
《中国当代医药》
2013年第16期63-64,共2页
China Modern Medicine
作者简介
通讯作者
