摘要
粘附斑激酶(focal adhesion kinase,FAK)是一种胞质非受体酪氨酸激酶,是整合素信号通路里一个重要的调节因子,在肿瘤细胞中高表达,与细胞迁移、粘附和侵袭有关。mTOR(mammalian target of rapamycin)是非典型性的Ser/Thr激酶,属于PIKK(phosphatidylinositol kinase-related kinase)超家族,介导营养信号调控细胞生长、分化及代谢等生理过程。近年的研究发现FAK通过三条途径与mTOR相关联,组成FAK/mTOR信号通路,在肿瘤细胞的增殖、迁移及肿瘤微环境中发挥着重要的调控作用。本文综述了FAK、mTOR和FAK/mTOR信号通路的特点及对肿瘤细胞调控作用的研究概况,为肿瘤治疗提供参考。
Focal adhesion kinase（ FAK） is a cytoplasmic nonreceptor protein-tyrosine kinase,which is identified as a key mediator of integrin signaling pathways. FAK is overexpressed in cancer cells and related migration,adhesion and invasion of tumor cells. The mammalian target of rapamycin（ m TOR） is an evolutionary conserved Ser / Thr kinase,and belongs to the phosphatidylinositol kinase-related kinase（ PIKK） superfamily. m TOR integrate signals from growth factors,nutrition and energy to regulate cell growth,differentiation and metabolism. FAK was found to be associated with m TOR to form FAK / m TOR signaling mediated by three pathways, which plays an important role in regulation of tumor cell proliferation,migration and microenviroment. This paper reviewed the characteristics FAK,m TOR and FAK / m TOR signaling pathway and the role of FAK / m TOR signaling on regulation of tumor cells,providing a reference for cancer therapy.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2016年第1期35-40,共6页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然基金项目(No.31160469
No.31360561)~~
作者简介
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