摘要
骨替代材料目前已成为拔牙位点保存术、牙槽嵴骨增量术和上颌窦底提升术的主要材料,而羟磷灰石、磷酸钙和生物活性玻璃以其良好的生物相容性、骨传导性、生物降解性、骨再生能力和骨结合率成为骨替代材料的代表。单一成分骨替代材料的诱导骨再生能力取决于材料本身的表面形貌、结构、成分、孔径和孔隙率。按不同比例复合的新型骨替代材料,可使原单一骨替代材料的性能得以互补。骨替代材料与血小板浓缩物的联合应用,可促进前成骨细胞的增殖与分化,激发成骨细胞的活动,促进血管新生,从而利于骨替代材料存活。骨替代材料与生长因子的联合应用,可获得不同程度骨结合和骨改建,增加材料的细胞黏附率,改善支架的力学性能,在骨愈合早期即能促进新骨形成。随着科技的进步,未来骨替代材料的成骨性能日臻完善,在口腔种植领域的应用前景将会更加广阔。
Bone graft substitutes are currently used in extraction site maintenance, alveolar ridge augmentation, and maxillary sinus floor augmentation. Hydroxylapatite, calcium phosphate, and bioactive glass are representative bone substitutes because of their biocompatibility, osteoconductibility, biodegradability, bone regeneration, and boneimplant contact ratios. The osteogenesis of bone substitutes depends on their morphology, structure, composition, pore size, and porosity. Combining two or more components in various proportions can produce new bone substitutes with excellent properties. For instance, the combined application of bone substitutes and platelet concentrates can promote the proliferation and differentiation of pre-osteoblasts and active osteoblasts, as well aspromote angiogenesis. In addition, bone substitutes combined with growth factors can promote new bone formation during early bone healing, acquire different levels of osseointegration and bone reconstruction, promote cell adhesion rate, and improve scaffold mechanics. Future studies should focus on optimizing the osteogenesis of bone substitutes and widening the applications of these substitutes in dental implantology.
出处
《国际口腔医学杂志》
CAS
北大核心
2016年第1期113-117,共5页
International Journal of Stomatology
基金
国家自然科学基金(81200809)
高等学校博士学科点专项科研基金(20120061110077)
吉林省科技发展计划项目(201305-22037JH)~~
关键词
口腔种植
骨替代材料
骨再生
骨结合
dental implants
bone substitutes
bone regeneration
osseointegration
作者简介
王晓娜，硕士，Email：Tina90520@163．com
【通信作者】周延民，教授，博士，Email：zhouym@jlu．edu．cn
