摘要
【目的】观察阿加曲班对急性脑梗死(ACI)患者血管内皮功能及炎症因子的影响。【方法】102例ACI患者被随机分为两组:对照组50例用常规治疗方法治疗,治疗组52例在常规治疗的基础上加用阿加曲班。于治疗前和治疗14 d后检测内皮功能及炎症因子指标,于治疗前和治疗14、28 d后评定神经功能缺损评分(NIHSS)和Barthel指数量表(MBI),于治疗28 d后评定临床疗效。【结果】治疗14 d后,治疗组患者的血管内皮功能(NO、ET-1、FMD)及炎症因子(hs-CRP、IL-6、TNF-α)均较对照组明显改善(P<0.05或P<0.01);治疗14及28 d后,治疗组患者的NIHSS及MBI均较对照组显著改善(均P<0.01);治疗28 d后,治疗组的总有效率高于对照组(P<0.05);治疗过程中未发现阿加曲班的不良反应。【结论】阿加曲班治疗急性脑梗死安全有效,可以改善NIHSS及MBI,除抗凝之外,改善血管内皮功能及抗炎可能也是其作用机制之一。
【Objective】 To evaluate the effect of argatroban on vascular endothelial function and inflammatory factors in the patients with acute cerebral infarction（ACI）. 【Methods】 A total of 102 patients with ACI patients were divided into two group： the control group（50 cases） received routine treatment, the treatment group（52 cases） increased argatroban on the basis of conventional treatment in the control group. To test the vascular endothelial function and inflammatory factors before treatment and after treatment of14 days. To test the score of neurological function defect assessment（NIHSS） and Barthel index（MBI） before treatment and after treatment of 14 day and 28 days. To evaluate the clinical efficacy after treatment of 28 days. 【Results】 After treatment of 14 days, the vascular endothelial function（NO, ET-1, FMD） and inflammatory factors（hs-CRP, IL-6, TNF-a） in the patients of the treatment group were significantly better than the control group（P〈0.05 or P〈0.01）. After treatment of 14 days, 28 days, NIHSS and MBI in the patients of the treatment group were significantly better than the control group（all P〈0.01）; After treatment of 28 days, the effective rate of the treatment group was significantly higher than that of the control group（P〈0.05）. Adverse reaction of argatroban was not found in the course of treatment. 【Conclusion】 Argatroban is safe and effective in the treatment of acute cerebral infarction,can improve the NIHSS and MBI, in addition to anticoagulation, one of the improvement of endothelial function and anti inflammatory vascular may be its mechanism of action.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2015年第6期870-876,共7页
Journal of Sun Yat-Sen University:Medical Sciences
基金
连云港市青年英才基金(DFQN1107)
关键词
阿加曲班
急性脑梗死
血管内皮功能
炎症因子
argatroban
acute cerebral infarction
vascular endothelial function
inflammatory factors
作者简介
王以翠，副主任医师，研究方向：神经内科学，E-mail：wangyicuilyg@163．com
