摘要
目的探讨致康胶囊对围绝经期功能失调性子宫出血患者血清性激素水平的影响。方法选择2011年3月至2014年3月在成都医学院第一附属医院接受治疗的围绝经期功能失调性子宫出血患者122例,按随机数字表法分为两组,各61例。对照组采用米非司酮治疗。观察组采用米非司酮联合致康胶囊治疗。于术后3 d口服米非司酮,每日25 mg,用药4周。致康胶囊每次3粒,每天3次,用药2周。观察治疗前后患者血清性激素包括黄体生成素(LH)、促卵泡生成素(FSH)、雌激素水平的改变。结果观察组总有效率为96.7%,高于对照组的82.0%,差异有统计学意义(P<0.01)。观察组有效控制出血时间、完全止血时间短于对照组[(17.3±3.7)h比(28.1±10.0)h,(35.7±10.8)h比(50.1±17.2)h],差异有统计学意义(P<0.01)。观察组血清LH水平为(20.2±2.5)U/L、FSH水平为(21.0±4.7)U/L、雌激素水平为(118.6±26.3)pmol/L,低于对照组的(32.5±4.5)U/L、(42.7±5.8)U/L、(250.1±33.5)pmol/L,差异有统计学意义(P<0.01)。治疗后,观察组患者的子宫内膜厚度小于对照组[(4.1±0.5)mm比(6.5±0.6)mm],差异有统计学意义(P<0.01)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论致康胶囊治疗围绝经期功能失调性子宫出血的疗效显著,并能调节患者血清性激素水平,且安全、可靠。
Objective To study the influence of zhikang capsule intervention on serum sex hormone lev- els in perlmenopausal patients with dysfunctional uterine bleeding. Methods A total of 122 perimenopausal patients with dysfunctional uterine bleeding from the First Affiliated Hospital of Chengdu Medical College during Mar. 2011 and Mar. 2014 were included in the study, and divided into two groups according to random number table method, 61 cases each. The control group was given the treatment of mifepristone. The observation group was given mifepristone combined with zhikang capsule. 3 days after the operation, the patients were given oral administration of mifepristone, one tablet per day, for 4 weeks, and zhikang cap- sule, 3 times a day and 3 pills each time, for 2 weeks. The changes of serum sex hormones,including luteini- zing hormone（LH） ,follicle stimulating hormone（FSH） and estrogen levels were observed before and after treatment. Results The total efficiency of the observation group was 96.7% higher than that of the control group 82. 0%, the difference was statistically significant （ P 〈 0. 01 ）. Effective control of bleeding time, complete hemostasis time of the observation group were less than that of the control group [ （ 17.3 ± 3.7 ） h vs （28. 1 ± 10. 0） h, （35.7 ± 10. 8） h vs （50. 1 ±17.2） hi, the difference was statistically significant（P 〈 0. 01 ）. The level of serum LH was（20. 2 ±2. 5） U/L, FSH level was（21.0 ±4. 7） U/L, and estrogen level was （ 118.6 ±26. 3） pmol/1, all lower than the control group, where the level of serum LH was （32.5 ± 4.5 ） U/L, FSH level （42.7± 5.8 ） U/L, and estrogen level （250. 1± 33.5 ） pmol/L; all of the above differences were statistically significant （P 〈 0. 01 ）. After treatment, the endometrial thickness in patients of the observation group was less than that of the control group [ （4. 1 ± 0.5 ） mm vs （6.5 ± 0. 6 ） mm ], the difference was statistically significant（ P 〈 0.01 ）. The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Zhikang capsule is effective, safe and reliable in the treatment of perimenopansal dysfunctional uterine bleeding, and can adjust the serum sex hormone levels in the patients.
出处
《医学综述》
2015年第22期4208-4210,共3页
Medical Recapitulate
