摘要
出口梗阻型便秘(outlet obstruction constipation,OOC)已经成为影响现代人生活质量的重要疾病之一。本文就近年来国内外有关OOC的发病机制及针刺八髎穴治疗OOC的研究进行了回顾,发现针刺八髎穴可能通过提高神经节内板状末梢改善机械扩张的敏感性,升高血清胆囊收缩素水平,抑制脊髓前角的γ-运动神经元、脊髓内侧角的交感中枢的兴奋性及减少5-羟色胺、组织胺的释放等多途径达到治疗OOC的作用。深入探讨八髎穴治疗OOC的作用机制,可为寻找更为特异和有效的治疗靶点提供实验依据和理论基础。
Outlet obstruction constipation（OOC）is a common clinical problem affecting many people＇s daily life quality nowadays.Acupuncture therapy is effective in easing OOC to reduce patients＇ sufferings by stimulation of Baliao-points i.e.,bilateral Shangliao（BL 31）,Ciliao（BL 32）,Zhongliao（BL 33）and Xialiao（BL 34）,which has been confirmed repeatedly in clinical practice.In the present paper,the authors reviewed development of studies on the underlying mechanisms of acupuncture stimulation of Baliao-points for OOC from：1）lowering the sensitivity of intraganglionic laminar nerve endings（rIGLEs）to rectal mechanical distension during defecation,2）raising the level of circulating cholecystokinin（CCK）to improve the sensory threshold of the rectum,3）lowering the excitability ofγ-motor neurons in the spinal anterior horns controlling the slow contraction of the rectal sphincter muscle,4）inhibiting the excitability of sympathetic output from the spinal lateral horns,5）easing the tonic contraction of the pelvic muscles to reduce the release of 5-hydroxy tryptamine（5-HT）,histamine,and other related chemical mediators due to local ischemia.Moreover,further study on the mechanism of acupuncture stimulation of Baliao-points underlying improving OOC may help up find more specific and effective therapeutic targets and provide more reliable experimental foundation and theoretical basis.
出处
《针刺研究》
CAS
CSCD
北大核心
2015年第5期427-430,共4页
Acupuncture Research
基金
"十二五"国家科技支撑计划项目(No.2012BAI 24B01)
江苏省中医药管理局项目(LZ 13104)
江苏省南京市中医院项目(No.YJ 201404)
关键词
八髎穴
出口梗阻型便秘
直肠低敏感性
盆底肌痉挛
Baliao-points
Outlet obstruction constipation
Rectal hyposensitivity
Pelvic floor muscle spasm
作者简介
第一作者：邹洋洋（1988-），男，硕士研究生在读，研究方向：针灸理论及临床应用。
通信作者：张建斌（1967-），男，副主任医师、副教授，研究方向：针灸理论及『临床应用。E-mail：zhangjianbin@njucm．edu．cn
