摘要
目的探讨频域光学相干断层扫描（OCT）检测的黄斑区神经节细胞复合体（mGCC）厚度与视网膜神经纤维层（RNFL）厚度，在原发性慢性闭角型青光眼（CPACG）早期诊断中的作用。方法临床病例对照研究。对2013年10月至2014年4月在承德医学院附属医院眼科采用RTV100—20CT对CPACG患者35例（35只眼）及正常人30名（30只眼）进行检测，比较两组间平均上方、下方mGCC厚度及平均上方、下方RNFL厚度的差异，评估各检测指标对早期CPACG的诊断效能。结果早期CPACG组平均mGCC厚度、上方mGCC厚度、下方mGCC厚度、平均RNFL厚度、上方RNFL厚度及下方RNFL厚度分别为（94．87±7．89）、（95．02±8．16）、（94．65±8．91）、（99．28±9．57）、（99．63±10．11）、（99．20±10．18）um，正常对照组分别为（116．12±17．75）、（117．02±16．28）、（116．04±21．28）、（124．81±21．71）、（125．32±19．91）、（124．35±25．89）um，组间比较差异均具有统计学意义（P〈0．05）。平均mGCC厚度、上方mGCC厚度、下方mGCC厚度、平均RNFL厚度、上方RNFL厚度及下方RNFL厚度ROC曲线下面积（AROC）分别为0．933、0．957、0．862、0．928、0．948、0．871；各检测参数AROC比较，平均RNFL厚度和下方RNFL厚度、平均mGCC厚度和下方平均mGCC厚度、平均mGCC厚度和上方平均mGCC厚度配对比较差异均有统计学意义（P〈0．05），其余配对比较差异均无统计学意义（P〉0．05）。结论频域OCT检测的mGCC及RNFL厚度对早期CPACG均具有良好地诊断能力。
Objective To explore the effect of macular ganglion cell complex （mGCC） thickness and retinal nerve fiber layer （RNFL） thickness measured with spectral domain optical coherence tomography （OCT） in early diagnosis of chronic primary angle-closure glaucoma （CPACG）. Methods Thirty-five patients （35 eyes） with CPACG and 30 normal cases were examined by using RTV100-2OCT. The differences of mGCC and RNFL thickness in average, superior and inferior between the two groups were compared. The ability of each parameter to detect early CPACG changes was assessed. Results In early CPACG group, average mGCC thickness, superior mGCC thickness, inferior mGCC thickness, average RNFL thickness, superior RNFL thickness and inferior RNFL thickness were （94.87±7.89）Bm, （95.02±8.16）Bm, （94.65±8.91）um, （99.28±9.57）um, （99.63±10.11）um, （99.20±10.18）um, respectively; in normal control group, the corresponding parameter thickness were （116.12 ± 17.75）um, （117.02 ±16.28）um, （116.04 ±21.28）um, （124.81 ±21.71）um, （125.32 ± 19.91）um, （124.35±25.89）um, respectively; differences between the two groups were statistically significant （P〈 0.05）. The areas under the receiver operating characteristic curves （AROC） of average mGCC thickness, superior mGCC thickness, inferior mGCC thickness, average RNFL thickness, superior RNFL thickness and inferior RNFL thickness were 0.933, 0.957, 0.862, 0.928, 0.948, 0.871, respectively; de- tection parameters AROC comparison, differences between average RNFL thickness and inferior RNFL thickness, average mGCC thickness and superior mGCC thickness, average mGCC thickness and inferior mGCC thickness were statistically significant （P〈0.05）, the remaining differences between paired were no statistically significant （P〉0.05）. Conclusions mGCC and RNFL thickness detected by spectral domain OCT has good diagnostic capabilities in early CPACG.
出处
《中国实用眼科杂志》
2015年第10期1101-1104,共4页
Chinese Journal of Practical Ophthalmology
作者简介
通信作者：张铁民，Email：MYH1979@aliyun．com
