摘要
通过查阅、整理、分析和总结相关文献资料,了解到:从3种开唇兰属植物中分离到包括金线莲苷在内的8种丁酸衍生物葡萄糖苷;金线莲苷具有降血糖、降血脂、保肝护肝和改善骨质疏松等的作用;人工合成金线莲苷方法包括化学方法,化学方法和酶促法相结合两种方法。金线莲苷药理活性确切,但其自然资源匮乏,人工合成金线莲苷得率低、条件难控制,因此,今后将围绕提高开唇兰植物中金线莲苷的提取率,明确金线莲苷体内的具体作用机制,并将其用于临床研究,明晰金线莲苷的生物合成途径展开。
Related references were researched, classified and analyzed. Eight glycosides of butanoic acid derivatives were isolated and identified. Kinsenoside had obvious antihyperglycemic, antihypersis and hepatoprotective activities, and also obvious bioactivities of preventing bone loss and anti inflammatory reactions. Its anticancer and antibacterial activities were not obvious. The artificial synthetic methods included chemical synthesis and chemical synthesis combined with enzymatic synthesis. Because of lacking natural recourses of kinsenoside and difficulties in artificial synthesis, future study will focus on improving extraction yield of kinsenosied from Anoectochilus plants, studying on specific action mechanism of kinsenoside, and interpreting the biosynthesis pathways.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第19期1795-1798,1802,共5页
Chinese Journal of Hospital Pharmacy
基金
浙江省自然科学基金(编号:LY14H280008)
浙江农林大科研发展基金人才启动项目(编号:2014FR062)
关键词
金线莲苷
丁酸衍生物葡萄糖苷
药理活性
人工合成
生物合成
kinsenoside
glucosides of butanoic acid derivatives
pharmacological activity
artificial synthesis
kinsenoside biosynthesis
作者简介
王建栋，男，研究方向：生物制药。电话：0571—63740813，E-mail：15068880474@126．com
[通讯作者]王红珍，女，博士，助理研究员，研究方向：药用植物分子生物学。电话；0571—63740898，E-mail：wang．hongzhen@163．com
