摘要
独活寄生汤是中医学中治疗风寒湿痹,肝肾两虚,气血不足证的经典方剂之一,随着现代药理研究的不断深入该方已广泛应用于膝骨关节炎治疗。为进一步探讨独活寄生汤治疗膝骨关节炎机制,对近五年来其治疗膝骨关节炎基础文献检索分析,发现其可能通过调控炎性细胞因子、促进软骨细胞增殖、抑制软骨细胞凋亡等方面起到积极作用,从而延缓关节软骨退变,减轻疼痛,改善关节功能等。
Angelicae pubescentis and loranthi decoction is one of the most classical prescription in TCM（ Traditional Chinese Medicine TCM ） . It can expel wind-damp, relieve pain, benefit to liver and kidney, and tonify Qi-blood effectively. As the development of pharmacology of TCM, this decoction is widely used in the treatment of KOA. In order to further investigate the mechanisms of angelicae pubescentis and loranthi decoction in KOA, we summarized the basic researches on the decoction in treating KOA in recent five years. We found that it may play an important role in regulating inflammatory, stimulating cartilage proliferation, and inhibiting cartilage apoptosis, thus it can delay articular cartilage degeneration, relieve pain, and improve joint function and so on.
出处
《环球中医药》
CAS
2015年第9期1149-1152,共4页
Global Traditional Chinese Medicine
基金
国家中医药管理局中医药重点学科建设项目(2013QK20)
上海中医药大学研究生"创新能力培养"专项科研项目(2015YCX14)
关键词
膝骨关节炎
独活寄生汤
综述
Knee Osteoarthritis
Angelicae pubescentis and loranthi decoction
Review
作者简介
吕顺（1989-），2013级在读硕士研究生。研究方向：中西医结合修复重建骨关节软骨。E—mail：lvshun1989@126．com
通信作者：周军杰（1975-），博士，副主任医师，硕士生导师。研究方向：中西医结合修复重建骨关节软骨。E-mail：boysroger@126．com
谢晓涛（硕士研究生）
