摘要
目的观察抗组胺药物、5-羟色胺受体阻滞剂及β-内啡肽拮抗剂治疗肝胆疾病所致皮肤瘙痒症的临床疗效及与相关瘙痒介质的关系。方法将肝胆疾病所致皮肤瘙痒症患者90例随机分为3组各30例,分别予以氯雷他定片、纳洛酮和格拉司琼治疗,观察治疗前后瘙痒症状评分及瘙痒程度直观模拟评分(IS)变化情况;分析患者组胺、5-羟色胺、β-内啡肽的变化与瘙痒症状评分变化的相关性。结果使用3种药物治疗后患者瘙痒症状积分及IS积分均有明显下降;组胺降低与瘙痒症状积分下降呈正相关,5-羟色胺及β-内啡肽的降低与瘙痒症状积分下降无关。结论 5-羟色胺受体阻滞剂格拉司琼及β-内啡肽拮抗剂纳洛酮治疗肝胆疾病所致皮肤瘙痒症有效。
Objective To observe the clinical effects and relationships between related pruritus medium of pruritus cutaneous assoxiated with hepatobiliary diseases treated by antihistamine drugs, 5-hydroxytryptamine receptor blockers and β-endorphine antagonist. Methods The patients suffered from pruritus cutaneous associated with hepatobiliary disea- ses were randomly divided into three groups and treated with loratadine, naloxone and granisetron respectively. The pruritus symptom scores and the intuitional analog scale （IS） of pruritus degree were observed before and after treatment. The correlation was analyzed between the changes of the histamine, 5-hydroxytryptamine and β-endorpbine and the pruri- tus symptom scores. Results The patients pruritus symptom scores and IS of pruritus degree declined obviously after related treatments. The degrees of decline were positively correlated between histamine and the pruritus symptom scores, but it were no correlation between 5-hydroxytryptamine and β-endorphine and the pruritus symptom scores. Conclusion Loratadine, naloxone and granisetron are effective in pruritus cutaneous associated with hepatobiliary diseases.
出处
《西部医学》
2015年第8期1203-1205,1208,共4页
Medical Journal of West China
基金
重庆市卫生局资助课题(2009-2-50)
作者简介
通讯作者：孙小平，E-mail：sxp_1977@163．com
