摘要
目的：探讨口腔卫生状况及慢性病与口腔鳞状细胞癌的关系。方法采用病例-对照研究方法，收集2010年9月至2015年1月经病理确诊的口腔鳞状细胞癌新发病例414例，同期收集来自社区的对照870例。采用统一编制的调查表，面访收集研究对象的人口学特征、吸烟史、饮酒史、饮茶史、口腔卫生、饮食习惯、肿瘤家族史、既往疾病史等，应用非条件logistic回归模型分析口腔卫生习惯及慢性病与口腔鳞状细胞癌发病风险的调整OR（95%CI）值；按照吸烟状况、饮酒状况及性别进行分层，分析不良修复体、复发性口腔溃疡及高血压与口腔鳞状细胞癌的关联。结果多因素分析发现，口腔鳞状细胞癌的危险因素有目前牙齿数为20~27颗及〈20颗（以目前牙齿数≥28颗为参照）、不良修复体、复发性口腔溃疡，其调整OR（95%CI）值分别为2.01（1.49~2.73）、3.51（2.39~5.15）、2.33（1.79~3.04）、3.96（2.11~7.44）；而刷牙频率为1次/d、刷牙频率〉1次/d、看牙医周期≥5年/次是口腔鳞状细胞癌的保护因素，其调整OR（95%CI）值分别为0.24（0.13~0.43）、0.13（0.07~0.24）、0.37（0.26~0.53）。分层分析发现，复发性口腔溃疡可增加非吸烟者和非饮酒者口腔鳞状细胞癌的发病风险，调整OR（95%CI）值分别为5.21（2.42~11.18）和4.71（2.37~9.36）；在非吸烟者和非饮酒者中，高血压与口腔鳞状细胞癌的发生存在关联，调整OR（95%CI）值分别为1.70（1.10~2.61）和1.58（1.07~2.34）。结论口腔卫生状况及慢性病对口腔鳞状细胞癌的发生有一定影响。
Objective To investigate the association between oral hygiene, chronic diseases, and oral squamous cell carcinoma. Methods We performed a case-control study with 414 cases and 870 controls in Fujian during September 2010 to January 2015. Patients were newly diagnosed oral squamous cell carcinoma cases according to the pathologic diagnoses, control subjects were enrolled from community population. Epidemiological data were collected by in-person interviews using a standard questionnaire . The contents of the questionnaire included demography character, history of tobacco smoking and alcohol drinking, dietary habits, oral hygiene status, family history of cancer, etc. Using unconditional logistic regression analysis to estimate adjusted odds ratios （OR） and corresponding 95% confidence intervals （CI） for oral hygiene and chronic diseases. We also stratified by sex, smoking and drinking to explore possible difference in association between subgroups. Results The multivariate logistic regression analysis indicated that number of teeth（20-27 and＆lt;20）, bad prosthesis, recurrent oral ulceration were the risk factors of oral squamous cell carcinoma, the adjusted OR（95%CI） values were 2.01（1.49-2.73）, 3.51（2.39-5.15）,＆amp;nbsp;2.33（1.79-3.04）, 3.96（2.11-7.44）, respectively;brushing tooth once per bay,brushing tooth more than once per day, regular oral health examination at least 5 years per time were the protective factors of oral squamous cell carcinoma, the adjusted OR（95%CI） values were 0.24 （0.13-0.43）,0.13 （0.07-0.24）, 0.37 （0.26-0.53）, respectively. The stratification analysis indicated that recurrent oral ulceration could increase the risk of oral squamous cell carcinoma for non-smokers and non-drinking, the adjusted OR（95%CI） value was 5.21（2.42-11.18） and 4.71（2.37-9.36）;and a risky effect of hypertension on risk of oral squamous cell carcinoma was observed for non-smokers and non-drinking, the adjusted OR（95%CI） values were 1.70 （1.10-2.61） and 1.58 （1.07-2.34） . Conclusions Oral hygiene and chronic diseases could affect the incidence of oral squamous cell carcinoma.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2015年第8期688-692,共5页
Chinese Journal of Preventive Medicine
基金
福建省科技厅科研项目（2015J01304）
福建省教育厅科研项目（JA13141）
福建医科大学公共卫生学院“环境与健康重点实验室”新技术研究与应用（201201）
作者简介
通信作者：蔡琳，Email：cailin_cn@hotmail．com
