摘要
药物性肝病是临床常见的药物不良反应之一,急性肝损伤是药物性肝病最常见的发病形式,少数可发生威胁生命的肝衰竭.药物性肝病的确诊,需要排除其他原因,而患者常常合并使用多种药物,不易判断是何种药物所导致的肝病,且出现临床症状之后,缺乏规范化的治疗.本文将药物性肝病的病理类别与常见保肝药物的作用机制作一综述.
Drug-induced liver disease is one of the adverse reactions of clinical drugs. Acute liver injury is the most common form of drug-induced liver disease and even could cause life-threatening liver failure. It is not easy to diagnose, and the diagnosis can be established only after other diagnoses excluded. In most cases, patients usually are prescribed several drugs together, which makes it even harder to distinguish and give standardized treatment. This review summarizes the pathological category of Drug- induced liver disease and the mechanisms of action of liver-protecing drugs.
出处
《世界华人消化杂志》
CAS
2015年第19期3045-3052,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81100289
81470852
上海市科委生物医药领域科技支撑基金资助项目
No.13431900503
上海市卫生系统优秀青年人才培养基金资助项目
No.XYQ2013091
上海交通大学医工交叉面上基金资助项目
No.YG2012MS02~~
关键词
药物性肝病
保肝药物
作用机制
Drug-induced liver disease
Liver-protecting drugs
Mechanism of action
作者简介
汤静，副主任药师，硕士生导师，主要从事临床药学的研究．
通讯作者：刘皋林，教授，主任药师，博士生导师，200080，上海市虹口区海宁路100号，上海交通大学附属第一人民医院临床药学科．gaolinliu@aliyun.com电话：021—37798317
