摘要
目的:观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗急性药物性肝损害的疗效。方法:将90例急性药物性肝损害患者,随机均分为Ⅰ、Ⅱ、Ⅲ组,各30例,分别予还原型谷胱甘肽、多烯磷脂酰胆碱及二者联用,静脉滴注。监测入院时,治疗1、2、4周时的肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)的变化,评估3组患者的肝功能恢复状况。结果:3组患者的ALT、AST和TBIL随治疗时间延长均呈下降趋势,其中Ⅲ组治疗1、2、4周时各指标与同期Ⅰ、Ⅱ组比较,差异有统计学意义(P<0.05)。结论:还原型谷胱甘肽联合多烯磷脂酰胆碱对急性药物性肝损害的疗效优于单一用药。
OBJECTIVE： To observe the therapeutic efficacy of reduced glutathione combined with polyene phosphatidylcholine in the treatment of acute drug-induced liver injury. METHODS ： A total of 90 patients with acute drug-induced liver injury were ran- domly divided into group Ⅰ , group Ⅱ , group Ⅲ with each group of 30 cases. Those groups received reduced glutathione, polyene phosphatidylcholine and combined therapy of them via iv.gtt, respectively. Changes of liver function parameters, including ALT, AST and TBIL of 3 groups were observed on admission, after 1, 2 and 4 weeks of treatment. The improvement of liver function was evaluated among 3 groups. RESULTS： With time prolonging, the levels of ALT, AST and TBIL in 3 groups were decreased. After 1, 2 and 4 weeks of treatment, there were significant differences in liver function parameters between group Ⅲ and group Ⅰ . Ⅱ （P〈0.05）. CONCLUSION： Reduced glutathione combined with polyene phosphatidylcholine is superior to single treatment lbr acute drug-induced liver injury.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第28期2642-2643,共2页
China Pharmacy
关键词
还原型谷胱甘肽
多烯磷脂酰胆碱
药物性肝损害
Reduced glutathione
Polyene phosphatidylcholine
Drug-induced liver injury
作者简介
副主任医师，本科。研究方向：消化系急重症的诊治。电话：0416—4197223。E—mail：aaapwz609@163．com
通讯作者：副主任医师，硕士研究生导师，博士。研究方向：消化系肿瘤的诊治。电话：0416—4197540。E—mail：jz7203@yahoo．com．cn
