摘要
目的探讨影响非酒精性脂肪性肝病患者肝脏受控衰减参数变化的相关影响因素。方法使用Fibrotouch诊断仪检测51例非酒精性脂肪性肝病患者肝脏受控衰减参数(CAP),同时获取受试者血脂、血生化指标,以及性别、年龄、体质指数(BMI)等资料,对其进行多元线性回归分析,建立回归方程。结果单因素分析显示,CAP值与BMI和ALT相关(P=0.001,P=0.036);多元线性回归分析发现,CAP值与BMI和ALT呈显著性正相关(F=10.728,P<0.0001),其标准回归系数分别为:体质指数,β=0.505,P=0.000;ALT,β=0.254,P=0.040;通过多元回归分析建立的模型分别为:CAP=49.547+6.809×BMI+2.82×ALT。结论非酒精性脂肪性肝病患者CAP值受体质指数和血清ALT的影响。
Objective To explore the influencing factors of controlled attenuation parameter （CAP） obtained by FibroTouch in patients with non-alcoholic fatty liver diseases. Methods Fifty-one patients with non-alcoholic fatty liver diseases were recruited in this study,and CAP measurement was conducted by Fibrotouch. Blood lipids, blood biochemical indexes,gender,age and body mass index（BMI） were collected. Multiple linear regression analysis was done for statistic analysis. Results Univariate analysis showed CAP value was positively related to BMI and ALT （P=0.001 for BMI;P=0.036 for ALT）;Muhiple linear regression analysis showed that CAP value was significantly correlated with BMI and ALT（F=10.728,P〈0.0001 ;standard regression coefficient of BMI β=0.505,P= 0.000;standard regression coefficient of ALT β=0.254,P=0.040） ,and the regression equation established after multiple linear regression analysis was CAP=49.547＋6.809×BMI＋2.82×ALT. Conclusion BMI and serum ALT levels might affect the results of FibroTouch examination in patients with non-alcoholic fatty liver diseases.
出处
《实用肝脏病杂志》
CAS
2015年第4期367-370,共4页
Journal of Practical Hepatology
基金
吉林省科技厅科研基金资助课题(2013c026-1)
作者简介
第一作者：王文睿，女，23岁，硕士研究生。主要从事脂肪性肝病防治研究。E-mail：wwenrui@163．com
通迅作者：金珍婧，E-mail：jinyu0429@sina．com
