摘要
目的：探讨中青年人群的血脂水平与人体成分之间的关系。方法根据人体成分检测结果，将642名受试者（21-60岁，男178人，女464人）分为正常（N）组272人，单纯肥胖（O）组245人和少肌症肥胖（SO）组125人，比较组间血脂谱的差异，并进行血脂异常的相关因素分析。结果 N组、O组、SO组的血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平逐渐升高，高密度脂蛋白胆固醇（HDL-C）水平逐渐降低（P〈0.01）；发生高TC、TG、LDL-C与低HDL-C血症的比值比逐渐升高[与N组相比，O组发生4项血脂异常的OR（95%CI）值分别为2.617（1.117-6.132）、3.549（1.481-8.503）、4.618（1.288-16.564）、1.222（0.529-2.822），SO组分别为5.915（2.512-13.926）、10.430（4.400-24.722）、9.522（2.637-34.388）、4.253（1.957-9.242）]；校正性别、年龄、腰臀比、内脏脂肪面积后，N组、O组、SO组发生高TG血症的比值比仍逐渐升高[与N组相比，O组的OR（95%CI）值为3.565（1.319-9.632），SO组为8.173（2.685-24.881）]。SO组发生高TC、低HDL-C血症的比值比也高于N组[OR（95%CI）值分别为5.658（1.871-17.111）、6.823（2.119-21.969）]。以有、无血脂异常为因变量分别对男性、女性进行多因素logistic回归分析发现，男性高TC、TG血症的关联因素分别是体脂百分比增加，少肌症、少肌症肥胖，低HDL-C血症的关联因素为少肌症；女性高TC、TG、LDL-C血症的关联因素分别为少肌症、增龄，体脂百分比增加、增龄，少肌症、增龄（P〈0.05）。结论中青年人群中肥胖伴有相对肌肉减少者容易发生血脂异常，其严重程度高于单纯性肥胖者。肌肉相对减少是男性高TG、低HDL-C血症，女性高TC、高LDL-C血症的关联因素。
Objective To explore the relationship between lipids profile and body composition in the young and middle-aged adults. Method The relationship between body composition and lipids profile was examined in 642 adults （21-60 years, 178 male, 464 female）. According to the result of body composition assessment, they were assigned to three groups： Normal （N, n=272）, Obesity （O, n=245）, Sarcopenic Obesity （SO, n=125）. The lipids profile among three groups and its related factors were analyzed. Results In groups N, O and SO, the levels of total cholesterol （TC）, triglycerides （TG）, low density lipoprotein-cholesterol （LDL-C） increased gradually （P〈0.01）, and the high density lipoprotein-cholesterol （HDL-C） level decreased gradually （P〈0.01）. In a multiple logistic regression analysis, the odds ratio for high levels of TC, TG, LDL-C and low level of HDL-C risk increased gradually in groups N, O and SO [compared to group N, the odds ratio of the four kinds of dyslipidemia in group O were 2.617 （1.117-6.132）, 3.549 （1.481-8.503）, 4.618 （1.288-16.564）, 1.222 （0.529-2.822）, respectively, and in group SO were 5.915 （2.512-13.926）, 10.430 （4.400-24.722）, 9.522 （2.637-34.388） , 4.253 （1.957-9.242） , respectively]. After＆amp;nbsp;adjusting for age, sex, waist-to-hip ratio and visceral fat area, the odds ratio for high level of TG risk still increased gradually in group N, O and SO [compared to group N, the odds ratio of group O was 3.565 （1.319-9.632）, and of group SO was 8.173 （2.685-24.881）]. Moreover, the odds ratio for high TC and low HDL-C levels of group SO were higher than those of group N [compared to group N, the odds ratio in group SO were 5.658 （1.871-17.111）, 6.823 （2.119-21.969） respectively]. With stepwise multivariate logistic regression analysis, for male, the related factors for high levels of TC, TG and low level of HDL-C were high percentage of body fat;sarcopenia, sarcopenia obesity;sarcopenia, respectively. For female, the related factors for high levels of TC, TG and LDL-C were sarcopenia, aging;high percrntage of body fat, aging;sarcopenia, aging, respectively. Conclusion SO was the main risk factor for dyslipidemia in young and middle-aged adults, even more severe than obesity alone and sarcopenia was the risk factor of high TG, low HDL-C levels for male;and the risk factor of high TC, high LDL-C levels for female.
出处
《中华健康管理学杂志》
CAS
2015年第3期186-190,共5页
Chinese Journal of Health Management
基金
十二五科技支撑计划课题（2012BAK21802-04）
国家863生物和医药技术领域课题（2014AA022306）
作者简介
通信作者：孙明晓，Email：sunmjngxia0@hotmail．com
