摘要
目的探讨阿尔茨海默病(AD)精神行为症状(BPSD)与血浆同型半胱氨酸(HCY)水平的关系。方法对符合《精神障碍诊断和统计手册(第4版)》(DSM-Ⅳ)诊断标准的102例AD患者及80例对照组老年人进行血浆HCY测定,采用神经精神问卷(NPI)对AD患者进行测评,分为伴有BPSD组与不伴BPSD组,分析BPSD与血浆HCY水平的关系。结果 AD患者血浆HCY水平为(17.47±1.83)μmol/L,高于对照组(13.08±1.90)μmol/L,差异有统计学意义(t=14.663,P<0.001),伴BPSD组血浆HCY水平(17.48±1.85)μmol/L与不伴BPSD组(17.63±1.60)μmol/L比较,差异无统计学意义(t=0.299,P>0.05)。结论高同型半胱氨酸血症可能参与AD发病机制,而与BPSD的发生无关。
Objective To explore the association ketween Behavioral and Psychological Symptoms of Dementia( BPSD)of Alzhe=imerˊs disease(AD)and plasma homocysteine(HCY)level. Methods Plasma homocysteine levels were measured in 102 patients with AD and 80 healthy controls. BPSD of AD was assessed ky Neuropsychiatric Inventory( NPI),plasma HCY level was compared ketween BPSD group and non-BPSD group. Results Plasma HCY levels were significantly higher in AD group(17. 47 ± 1. 83)μmol/L than that in control group(13. 08 ± 1. 90)μmol/L(t=14. 663,P﹤0. 001). HCY levels had no difference ketween BPSD group (17. 46 ± 1. 85)μmol/L and non-BPSD group(17. 63 ± 1. 60)μmol/L(t=0. 299,P﹥0. 05). Conclusion Hyperhomocysteine may tade part in the pathogenesis of AD. HCY levels are not correlated to BPSD.
出处
《四川精神卫生》
2015年第3期203-205,共3页
Sichuan Mental Health
关键词
阿尔茨海默病
精神行为症状
同型半胱氨酸
Alzheimer 's disease
Behavioral and psychological symptoms
Homocystenine
作者简介
孙振晓,E-mail：szx.ywk＠163.com
