摘要
目的总结胃食管反流病(GERD)的常用方剂及药对规律。方法检索1994—2014年中医药治疗GERD的相关文献,提取辨证分型、用药等信息,建立Microsoft Excel 2003数据库,采用Crosstabs方法分析各证型、方剂、药对出现频次。结果共纳入文献350篇,常见6种基本证型,依次为肝胃不和证、脾虚湿热证、肝胃郁热证、痰气交阻证、中虚气逆证、脾胃虚寒证;共使用方剂109个,中药143种。GERD肝胃不和证治疗以柴胡疏肝散为主;脾虚湿热证以半夏泻心汤居多;肝胃郁热证常用左金丸;痰气交阻证以半夏厚朴汤为主;中虚气逆证以旋覆代赭汤为主;脾胃虚寒证黄芪建中汤多见。文献中高频使用的药对组合是半夏-黄连、黄芩-黄连、芍药-甘草、柴胡-白芍等共19对。结论中医药治疗GERD重视辨证论治的思想,多在主方、主药的基础上,综合考虑本证型病机特点,适当配伍其他类药物,或使其兼顾病机更加广泛,提高主药治疗效果,或防止主药作用太过,佐制其潜在副作用。
Objective To summarize the law of commonly used prescriptions and couplet medicines for gastroesophageal reflux disease （GERD）. Methods Medical literature on traditional Chinese medicine treatment of GERD published between the year 1994 and 2014 was reviewed. Information such as syndrome differentiation, medications for various types, etc. was extracted to establish a database with Microsoft Excel 2003. Frequency analysis for syndromes, prescriptions, and couplet medicines were conducted use the Crosstabs method. Results A total of 350 articles were included in the database. There were 6 common basic syndromes, including syndrome of incoordination between liver and stomach, syndrome of dampness-heat due to spleen deficiency, stagnated heat in liver and stomach syndrome, qi stagnation and phlegm stasis syndrome, spleen-hypofunction and reverse qi syndrome, and deficiency cold in spleen and stomach syndrome. A total of 109 prescriptions and 143 traditional Chinese medicines were used. GERD with syndrome of incoordination between liver and stomach treated mainly with Chaihu Shugan Powder （ 柴胡疏肝散） ; syndrome of dampness-heat due to spleen deficiency mainly with Banxia Xiexin Decotion （ 半夏泻心汤 ） ; syndrome of stagnated heat in liver and stomach syndrome commonly with Zuojin Pill （左金丸） ; syndrome of qi stagnation and phlegm stasis syndrome mainly with Banxia Houpu Decotion （半夏厚朴汤） ; syndrome of spleen-hypofunction and reverse qi syndrome mainly with Xuanfu Daizhe Decoction （旋覆代赭汤） ; and syndrome of eficiency cold in spleen and stomach syndrome with Huangqi Jianzhong Decoction （黄芪建中汤）. The 19 couplet medicines with high frequency use in the literature include Banxia （Pinellia, 半夏） and Huanglian （Coptidis, 黄连）, Huangqin （Radix Scutellariae Baicalensis, 黄芩 ） and Huanglian （Coptidis, 黄连 ） , Shaoyao （Peony, 芍药 ） and Chaihu （Licorice, Bupleurum, 柴胡 ） and Baishao （Radices Paeoniae Alba, 白芍 ）. Conclusion Chinese medicine treatment of GERD pays attention to syndrome differentiation theory. Starting from the overall concept, there are some rules to follow. Based on the main prescriptions and main medicines, considering the characteristics of pathogenesis syndrome comprehensively, the other drugs should be combined appropriately, so that to take into account the pathogenesis more extensively to improve the therapeutic effect of main drugs, or to prevent the over-effect of main drugs, or resist the potential side effects of drugs.
出处
《中医杂志》
CSCD
北大核心
2015年第10期881-883,共3页
Journal of Traditional Chinese Medicine
基金
北京市科技计划(Z141100002214012)
关键词
胃食管反流病
方剂
药对
gastroesophageal reflux disease
Chinese prescription
couplet medicines
作者简介
通讯作者：lbs0008@sina．com，（010）62835451
